Dlk1 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity. Involved in negative regulation of fat cell differentiation and negative regulation of vascular endothelial cell proliferation. Acts upstream of or within several processes, including bone mineralization; negative regulation of Notch signaling pathway; and positive regulation of bone resorption. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and musculoskeletal system. Orthologous to human DLK1 (delta like non-canonical Notch ligand 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Dlk1 |
| Official Name | delta like non-canonical Notch ligand 1 [Source:MGI Symbol;Acc:MGI:94900] |
| Ensembl ID | ENSMUSG00000040856 |
| Bio databases IDs | |
| Aliases | delta like non-canonical Notch ligand 1 |
| Synonyms | AC165954.1, delta, Delta1, Delta-like 1 homolog, delta like non-canonical Notch ligand 1, DLK, DlkI, FA1, foetal antigen 1, Ly107, Peg9, pG2, PREF1, SCP1, ZOG, δ, δ-like 1 homolog, δ-like dlk homeotic, δ like non-canonical Notch ligand 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dlk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- ectodomain
- intracellular domain
- protein binding
- membrane-proximal domain
- EGF_CA
Pathways
Biological processes and signaling networks where the Dlk1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- hyperlipidemia
- neoplasia
- glioblastoma
- central precocious puberty
- obesity
- growth failure
- bronchiolo-alveolar adenocarcinoma
- broncho-alveolar lung cancer
- hepatic fibrosis
phenotypes
- abnormal bone structure
- decreased bone mineral content
- decreased circulating glucose level
- decreased lean body mass
- increased total body fat amount
- preweaning lethality incomplete penetrance
- abnormal B cell number
- abnormal fat pad morphology
- abnormal placenta labyrinth morphology
- abnormal placental labyrinth vasculature morphology
- abnormal spleen B cell follicle morphology
- abnormal spleen marginal zone morphology
- abnormal survival
- asymmetric rib joints
- decreased body size
- decreased body weight
- decreased fat cell size
- decreased immature B cell number
- decreased litter size
- decreased mature B cell number
- decreased trophoblast glycogen cell number
- enlarged liver
- fetal growth retardation
- hepatic steatosis
- hyperlipidemia
- increased IgG1 level
- increased IgG2a level
- increased IgG2b level
- increased IgG2c level
- increased IgG3 level
- increased IgM level
- increased circulating cholesterol level
- increased fat cell size
- increased immature B cell number
- increased immunoglobulin level
- increased marginal zone B cell number
- increased transitional stage B cell number
- maternal imprinting
- narrow eye opening
- neonatal lethality
- neonatal lethality incomplete penetrance
- placental labyrinth hypoplasia
- postnatal growth retardation
- postnatal lethality
- rib fusion
role in cell
- expression in
- activation in
- growth
- formation
- upregulation in
- survival
- phosphorylation in
- production in
- differentiation
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
- plasma membrane extracellular face
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dlk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell differentiation
- negative regulation of Notch signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding