Myorg Gene Summary [Mouse]
Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds. Acts upstream of or within positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and skeletal muscle fiber development. Located in endoplasmic reticulum membrane and nuclear membrane. Is expressed in several structures, including alimentary system; brain; connective tissue; genitourinary system; and hemolymphoid system gland. Used to study basal ganglia calcification. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human MYORG (myogenesis regulating glycosidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myorg |
| Official Name | myogenesis regulating glycosidase (putative) [Source:MGI Symbol;Acc:MGI:2140300] |
| Ensembl ID | ENSMUSG00000046312 |
| Bio databases IDs | |
| Aliases | myogenesis regulating glycosidase (putative) |
| Synonyms | AA408153, Gm762, IBGC7, KIAA1161, myogenesis regulating glycosidase, myogenesis regulating glycosidase (putative), NET37, RGD1309821 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myorg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl hydrolases family 31
- Alpha amylase catalytic domain family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- endoplasmic reticulum membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myorg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- skeletal muscle fiber development
- positive regulation of protein kinase B signaling cascade
- positive regulation of insulin-like growth factor receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear membrane
Molecular Function
What the gene product does at the molecular level
- hydrolase activity, hydrolyzing O-glycosyl compounds