Ncln Gene Summary [Mouse]
Predicted to enable ribosome binding activity. Predicted to be involved in several processes, including multi-pass transmembrane protein insertion into ER membrane; protein stabilization; and regulation of protein complex stability. Predicted to be part of multi-pass translocon complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in neural retinal epithelium; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human NCLN (nicalin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ncln |
| Official Name | nicalin [Source:MGI Symbol;Acc:MGI:1926081] |
| Ensembl ID | ENSMUSG00000020238 |
| Bio databases IDs | |
| Aliases | nicalin |
| Synonyms | 3100002P13RIK, LOC56926, NET59, NICALIN, RGD1309355 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ncln often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc peptidases M18, M20, M28, and M42
- peptidase
- ribosome binding
- protein binding
- Peptidase family M28
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ncln gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- determination of left/right asymmetry in lateral mesoderm
- regulation of protein complex assembly
- protein stabilization
- regulation of signal transduction
- negative regulation of nodal signaling pathway
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- ribosome binding