Nptx2 Gene Summary [Rat]
Predicted to enable carbohydrate binding activity and metal ion binding activity. Involved in neurotransmitter receptor localization to postsynaptic specialization membrane. Is active in glutamatergic synapse and synaptic cleft. Is extrinsic component of postsynaptic specialization membrane. Orthologous to human NPTX2 (neuronal pentraxin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nptx2 |
| Official Name | neuronal pentraxin 2 [Source:RGD Symbol;Acc:1309447] |
| Ensembl ID | ENSRNOG00000001006 |
| Bio databases IDs | |
| Aliases | neuronal pentraxin 2 |
| Synonyms | NARP, neuronal pentraxin 2, NP2, NP-II, Pentraxin-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nptx2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Concanavalin A-like lectin/glucanases superfamily
- LamG
- signal peptide
- coiled-coil domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- preeclampsia
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- colorectal cancer
- dyskinesia
- aldosterone producing adrenocortical adenoma
- adenoma formation
- Wilms tumor
- abdominal aortic aneurysm
role in cell
- proliferation
- quantity
- apoptosis
- migration
- invasion
- connection
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- presynaptic regions
- cell surface
- somatodendritic region
- Plasma Membrane
- synapse
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nptx2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic transmission
- associative learning
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- carbohydrate binding