Ppa1 Gene Summary [Mouse]
Enables pyrophosphatase activity. Predicted to be involved in phosphate-containing compound metabolic process. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; cranium; integumental system; sensory organ; and telencephalon. Orthologous to human PPA1 (inorganic pyrophosphatase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppa1 |
| Official Name | pyrophosphatase (inorganic) 1 [Source:MGI Symbol;Acc:MGI:97831] |
| Ensembl ID | ENSMUSG00000020089 |
| Bio databases IDs | |
| Aliases | pyrophosphatase (inorganic) 1 |
| Synonyms | 2010317E03RIK, HEL-S-66p, inorganic pyrophosphatase 1, IOPPP, IPYR, PP, PP1, Pyp, Pyrophosphatase Inorganic, pyrophosphatase (inorganic) 1, Pyrophosphatase inorganic 1, Pyrophosphate Phosphohydrolase, SID6-8061 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Inorganic pyrophosphatase
- pyrophosphatase
- enzyme
- inorganic diphosphatase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- diabetic nephropathy
- lung adenocarcinoma
- lung adenocarcinoma formation
- colorectal cancer
- colorectal adenoma
- colorectal adenoma formation
- idiopathic scoliosis
regulates
- NAD+
- AMP
- ADP-D-ribose
- pyrophosphate
role in cell
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphate-containing compound metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- inorganic diphosphatase activity