Ptp4a1 Gene Summary [Mouse]
Predicted to enable protein tyrosine phosphatase activity. Involved in positive regulation of cell migration. Predicted to be located in cytoplasmic side of plasma membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; nervous system; nose; retina; and skeleton. Orthologous to human PTP4A1 (protein tyrosine phosphatase 4A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptp4a1 |
| Official Name | protein tyrosine phosphatase 4a1 [Source:MGI Symbol;Acc:MGI:1277096] |
| Ensembl ID | ENSMUSG00000026064 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase 4a1 |
| Synonyms | C130021B01, HH72, LOC100360241, LOC102547074, LOC103693189, PRL-1, PRL-CAAX1, protein tyrosine phosphatase 4A1, Ptp4a1 1, PTPCAAX1, PTP(CAAX1) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptp4a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Dual specificity phosphatase, catalytic domain
- protein-tyrosine-phoshatase
- catalytic domain
- phosphatase
- PTP_DSP_cys
- protein binding
- Protein tyrosine phosphatase, catalytic domain motif
- farnesylation site
- PTPase domain
Pathways
Biological processes and signaling networks where the Ptp4a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- chronic lymphocytic leukemia
- epileptic seizure
- androgenic alopecia
- psoriasis
- endometriosis
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- lung squamous cell carcinoma
role in cell
- motility
- proliferation
- migration
- expression in
- activation in
- signaling in
- binding in
- mitosis
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- spindle apparatus
- perinuclear region
- Plasma Membrane
- endosomes
- centrosome
- Endoplasmic Reticulum
- centriole
- cytoplasmic face of plasma membrane
- spindle fibers
- early endosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptp4a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- early endosome
- cytoplasm
- spindle
- endoplasmic reticulum
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein tyrosine phosphatase activity