Slc27a5 Gene Summary [Mouse]
Enables cholate-CoA ligase activity and fatty acid transmembrane transporter activity. Acts upstream of or within several processes, including ketone body biosynthetic process; long-chain fatty acid import across plasma membrane; and triglyceride mobilization. Located in basal plasma membrane. Is expressed in liver. Orthologous to human SLC27A5 (solute carrier family 27 member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc27a5 |
| Official Name | solute carrier family 27 (fatty acid transporter), member 5 [Source:MGI Symbol;Acc:MGI:1347100] |
| Ensembl ID | ENSMUSG00000030382 |
| Bio databases IDs | |
| Aliases | solute carrier family 27 (fatty acid transporter), member 5 |
| Synonyms | ACSB, ACSVL6, BACS, BAL, Bile Acid-Coa Synthetase, FACVL3, FATP-5, Fatty Acid-Coa Ligase, LOC79111, Rbal, rBAL-1, solute carrier family 27 (fatty acid transporter), member 5, solute carrier family 27 member 5, VLACSR, VLCS-H2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc27a5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- fatty acid transporter
- Adenylate forming domain, Class I superfamily
- O-succinylbenzoate-CoA ligase
- protein binding
- fatty-acid ligase
- long-chain-fatty-acid-CoA ligase
- long-chain fatty acid transporter
- binding protein
- AMP-binding enzyme
- CoA-ligase
- cholate-CoA ligase
- AMP-binding enzyme C-terminal domain
- amino acid adenylation domain
- transporter
Pathways
Biological processes and signaling networks where the Slc27a5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatitis B virus-related hepatocellular carcinoma
- liver cancer
- liver cirrhosis
- colorectal cancer
- nonalcoholic fatty liver disease
- proximal tubular toxicity
- hepatic fibrosis
- carbon tetrachloride-induced liver fibrosis
- insomnia
role in cell
- binding in
- expression in
- sorafenib resistance
- upregulation in
- downregulation in
- accumulation in
- alternative splicing in
- peroxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- Plasma Membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- basal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc27a5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty acid import
- long-chain fatty acid metabolic process
- ketone body biosynthetic process
- establishment of localization in cell
- plasma membrane long-chain fatty acid transport
- very long-chain fatty acid metabolic process
- bile acid biosynthetic process
- bile acid metabolic process
- triglyceride mobilization
- bile acid and bile salt transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- basal plasma membrane
- endoplasmic reticulum
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- very long-chain fatty acid-CoA ligase activity
- ATP binding
- fatty acid transporter activity
- protein binding
- oxidoreductase activity
- long-chain fatty acid-CoA ligase activity
- cholate-CoA ligase activity
- long-chain fatty acid transporter activity