Selenos Gene Summary [Mouse]
This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion (PMID:23614019). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2017]
Details
| Type | Protein Coding |
| Official Symbol | Selenos |
| Official Name | selenoprotein S [Source:MGI Symbol;Acc:MGI:95994] |
| Ensembl ID | ENSMUSG00000075701 |
| Bio databases IDs | |
| Aliases | selenoprotein S |
| Synonyms | 1500011E07Rik, AD-015, ADO15, H-4, H-47, RATSG2, SBBI8, selenoprotein S, SELS, SEPS1, sg2, VIMP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Selenos often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase binding
- protease binding
- cytoplasmic domain
- Selenoprotein S (SelS)
- enzyme binding
- antioxidant enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- muscle weakness
- ischemic stroke
- hepatic steatosis
- androgenic alopecia
role in cell
- expression in
- survival
- transport in
- response
- adipogenesis
- response by
- gluconeogenesis in
- endoplasmic reticulum stress response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- microsome
- smooth endoplasmatic reticulum
- cytoplasmic microtubule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Selenos gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of nitric oxide metabolic process
- negative regulation of inflammatory response
- negative regulation of glycogen biosynthetic process
- negative regulation of glucose import
- cell redox homeostasis
- regulation of gluconeogenesis
- ER overload response
- cellular response to insulin stimulus
- establishment of protein localization
- negative regulation of interleukin-6 production
- response to redox state
- response to glucose stimulus
- negative regulation of acute inflammatory response to antigenic stimulus
- cellular response to lipopolysaccharide
- endoplasmic reticulum unfolded protein response
- negative regulation of nitric-oxide synthase biosynthetic process
- cellular response to oxidative stress
- retrograde protein transport, ER to cytosol
- negative regulation of macrophage apoptotic process
- negative regulation of tumor necrosis factor production
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- very-low-density lipoprotein particle
- low-density lipoprotein particle
- endoplasmic reticulum
- cytoplasmic microtubule
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- antioxidant activity
- signaling receptor activity
- enzyme binding
- ATPase binding