Sec24b Gene Summary [Mouse]
Predicted to enable SNARE binding activity and zinc ion binding activity. Acts upstream of or within several processes, including artery morphogenesis; nervous system development; and regulation of establishment of planar polarity involved in neural tube closure. Part of COPII vesicle coat. Is expressed in cochlear duct and embryo. Orthologous to human SEC24B (SEC24 homolog B, COPII coat complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sec24b |
| Official Name | Sec24 related gene family, member B (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:2139764] |
| Ensembl ID | ENSMUSG00000001052 |
| Bio databases IDs | |
| Aliases | Sec24 related gene family, member B (S. cerevisiae) |
| Synonyms | AI605202, SEC24, SEC24 homolog B, COPII coat complex component |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sec24b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sec23/Sec24 helical domain
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- Sec23/Sec24 trunk domain
- zinc ion binding
- Gelsolin repeat
- vWFA
- Sec23/Sec24 beta-sandwich domain
- protein binding
- Sec23/Sec24 zinc finger
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- vesicles
- cytosol
- endoplasmic reticulum membrane
- transport vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sec24b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- auditory receptor cell stereocilium organization
- lung lobe morphogenesis
- pulmonary artery morphogenesis
- coronary artery morphogenesis
- cochlear nucleus development
- regulation of establishment of planar polarity involved in neural tube closure
- outflow tract morphogenesis
- cargo loading into COPII-coated vesicle
- intracellular protein transport
- ER to Golgi vesicle-mediated transport
- aorta morphogenesis
- neural tube closure
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- ER to Golgi transport vesicle membrane
- cytosol
- endoplasmic reticulum exit site
- COPII vesicle coat
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- SNARE binding