LZTR1 Gene Summary [Human]
This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | LZTR1 |
| Official Name | leucine zipper like transcription regulator 1 [Source:HGNC Symbol;Acc:HGNC:6742] |
| Ensembl ID | ENSG00000099949 |
| Bio databases IDs | |
| Aliases | leucine zipper like transcription regulator 1 |
| Synonyms | 1200003E21Rik, BTBD29, leucine zipper like post translational regulator 1, leucine-zipper-like transcriptional regulator, 1, NS10, NS2, SWNTS2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LZTR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- transcription regulator
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- enzyme binding
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pervasive developmental disorder
- hepatocellular carcinoma
- Noonan syndrome type 10
- Noonan spectrum disorder
- Noonan syndrome
- schwannomatosis type 2
- liver cancer
- epithelial cancer
- Noonan syndrome type 2
- central nervous system cancer
regulates
- zymosan
- Myelin
role in cell
- apoptosis
- phagocytosis
- phagocytosis by
- palbociclib resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endomembrane system
- Golgi Apparatus
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LZTR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of Ras protein signal transduction
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- endomembrane system
- Golgi apparatus
- recycling endosome membrane
- Cul3-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding