RNASE3 Gene Summary [Human]
The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014]
Details
| Type | Protein Coding |
| Official Symbol | RNASE3 |
| Official Name | ribonuclease A family member 3 [Source:HGNC Symbol;Acc:HGNC:10046] |
| Ensembl ID | ENSG00000169397 |
| Bio databases IDs | |
| Aliases | ribonuclease A family member 3, eosinophil cationic protein |
| Synonyms | ECP, RAF1, Ribonuclease 3, ribonuclease A family member 3, RNS3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNASE3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Non-5' phosphomonoester producing endoribonuclease
- ribonuclease
- enzyme
- RNase_A
- lipopolysaccharide binding
Pathways
Biological processes and signaling networks where the RNASE3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- septic shock
- psoriasis
- reactive eosinophilia with malignancy
- eosinophilic myocarditis
- asthma
- pustulosis palmaris et plantaris
- systemic lupus erythematosus
- idiopathic hypereosinophilic syndrome
- reactive eosinophilia with inflammation
- chronic periodontal disease
role in cell
- growth
- cell death
- binding
- osteogenic differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- azurophil granule lumen
- granules
- specific granules
- secretory granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNASE3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- innate immune response in mucosa
- defense response to Gram-negative bacterium
- induction of bacterial agglutination
- innate immune response
- antibacterial humoral response
- defense response to Gram-positive bacterium
- RNA catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- endonuclease activity
- ribonuclease activity
- lipopolysaccharide binding