TNFSF10
TNFSF10 Gene Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Details
| Type | Protein Coding |
| Official Symbol | TNFSF10 |
| Official Name | TNF superfamily member 10 [Source:HGNC Symbol;Acc:HGNC:11925] |
| Ensembl ID | ENSG00000121858 |
| Bio databases IDs | |
| Aliases | TNF superfamily member 10 |
| Synonyms | A330042I21RIK,APO-2L,Apo-2 ligand,CD253,Ly81,TANCR,TL2,TNF superfamily member 10,TNLG6A,TRAIL,tumor necrosis factor (ligand) superfamily, member 10,tumour necrosis factor (ligand) superfamily, member 10,tumour necrosis factor related apoptosis inducing ligand |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- extracellular domain
- TNF homology domain
- zinc ion binding
- TNF
- TRAIL binding
- protein binding
- receptor binding
- cytokine
- identical protein binding
Pathways
Biological processes and signaling networks where the TNFSF10 gene plays a role, providing insight into its function and relevance in health or disease.
- Chronic Myeloid Leukemia Signaling
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Death Receptor Signaling
- Erythropoietin Signaling
- Hepatic Cholestasis
- HMGB1 Signaling
- IL-17 Signaling
- Natural Killer Cell Signaling
- Nur77 Signaling in T Lymphocytes
- RAR Activation
- Retinoic acid Mediated Apoptosis Signaling
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- TNFRSF10B
- IRF1
- SPP1
- AR
- IRF2
- TNFRSF10D
- TNFRSF10A
- FADD
- CELF1
- CFLAR
disease
- neoplasia
- cancer
- papillary thyroid carcinoma
- epithelial cancer
- epithelial neoplasia
- melanoma cancer
- hyperplasia
- non-insulin-dependent diabetes mellitus
- rheumatoid arthritis
- insulin-dependent diabetes mellitus
regulated by
- YAP1
- dexamethasone
- valproic acid
- interferon alpha
- MYC
- ENV
- TNFSF10
- U937 cells
- Influenza A virus (A/Wisconsin/67/2005(H3N2))
- CEBPA
regulates
- lipid
- IL6
- IFNG
- PARP
- ALP
- MAPK8
- Ap1
- CASP3
- luciferase reporter gene
- synthetic promoter
role in cell
- quantity
- apoptosis
- expression in
- necrosis
- activation in
- cellular infiltration by
- infiltration by
- production in
- fragmentation in
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- Plasma Membrane
- lysosome membrane
- cytoplasmic vesicles
- multivesicular bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TNFSF10 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- immune response
- response to insulin stimulus
- male gonad development
- signal transduction
- positive regulation of release of cytochrome c from mitochondria
- apoptotic process
- positive regulation of apoptotic process
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- cell-cell signaling
- positive regulation of extrinsic apoptotic signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular vesicular exosome
- extracellular region
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- protein binding
- tumor necrosis factor receptor binding
- cytokine activity
- receptor binding
- TRAIL binding