Clec3b Gene Summary [Mouse]
Predicted to enable calcium ion binding activity; heparin binding activity; and kringle domain binding activity. Involved in ossification and positive regulation of plasminogen activation. Acts upstream of or within skeletal system development. Located in cytoplasm. Is expressed in several structures, including genitourinary system; gut; integumental system; serum; and skeletal musculature. Used to study Scheuermann's disease. Human ortholog(s) of this gene implicated in osteoarthritis and retinal macular dystrophy 4. Orthologous to human CLEC3B (C-type lectin domain family 3 member B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clec3b |
| Official Name | C-type lectin domain family 3, member b [Source:MGI Symbol;Acc:MGI:104540] |
| Ensembl ID | ENSMUSG00000025784 |
| Bio databases IDs | |
| Aliases | C-type lectin domain family 3, member b |
| Synonyms | C-type lectin domain family 3 member B, C-type lectin domain family 3, member B, LOC100912012, MCDR4, TETRANECTIN, TN, TNA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clec3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- calcium ion binding
- protein domain specific binding
- protein binding
- carbohydrate binding
- heparin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- serous ovarian adenocarcinoma
- serous ovarian cancer
- COVID-19
- retinal macular dystrophy type 4
- colorectal cancer
- diabetic nephropathy
- Alzheimer disease
- placenta accreta spectrum
- primary colorectal cancer
- Hutchinson-Gilford progeria syndrome
regulates
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- Cytoplasm
- granular components
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clec3b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to transforming growth factor beta stimulus
- bone mineralization
- ossification
- positive regulation of plasminogen activation
Cellular Component
Where in the cell the gene product is active
- granular component
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- platelet dense granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- kringle domain binding
- heparin binding
- carbohydrate binding