Fgf13 Gene Summary [Mouse]

Enables sodium channel regulator activity; transmembrane transporter binding activity; and tubulin binding activity. Involved in several processes, including learning or memory; negative regulation of cellular component organization; and nervous system development. Acts upstream of or within branching morphogenesis of a nerve; learning or memory; and neurogenesis. Located in several cellular components, including growth cone; intercalated disc; and lateral plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; integumental system; peripheral nervous system; and sensory organ. Used to study intellectual disability. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 90 and non-syndromic X-linked intellectual disability. Orthologous to human FGF13 (fibroblast growth factor 13). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Fgf13
Official Name
fibroblast growth factor 13 [Source:MGI Symbol;Acc:MGI:109178]
Ensembl ID
ENSMUSG00000031137
Bio databases IDs NCBI: 14168 Ensembl: ENSMUSG00000031137
Aliases fibroblast growth factor 13
Synonyms DEE90, Fgf1c, FGF2, FHF-2, fibroblast growth factor 13, LINC00889, LOC730528, XLID110
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgf13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • beta-tubulin binding
  • protein kinase activator
  • microtubule binding
  • beta-trefoil_FGF
  • ion channel binding
  • sodium channel regulator
  • protein binding
  • growth factor

Pathways

Biological processes and signaling networks where the Fgf13 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • epithelial cancer
  • seizures
  • oral squamous cell carcinoma
  • squamous cell cancer of the oral cavity
  • epilepsy
  • developmental and epileptic encephalopathy type 90
  • Alzheimer disease
  • Huntington disease
  • Parkinson disease
  • congenital generalized hypertrichosis
regulated by
  • Cdkn2a
  • tretinoin
  • thapsigargin
  • rosiglitazone
  • MEN1
  • phorbol 12,13-dibutyrate
  • EZH2
  • estrogen receptor
  • TP53
  • NFE2L2
regulates
role in cell
  • expression in
  • proliferation
  • phosphorylation in
  • apoptosis
  • formation
  • synthesis in
  • quantity
  • migration
  • branching
  • depolymerization

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • Cytoplasm
  • cell surface
  • Nucleus
  • Plasma Membrane
  • microtubules
  • intercellular junctions
  • cytosol
  • lateral plasma membrane
  • nucleoli
  • growth cone
  • neurites
  • filopodia
  • axons
  • dendrites

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgf13 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • signal transduction
  • cell-cell signaling
  • nervous system development
  • negative regulation of microtubule depolymerization
  • microtubule polymerization
  • branching morphogenesis of a nerve
  • hippocampus development
  • learning
  • memory
  • cerebral cortex cell migration
  • MAPK cascade
  • negative regulation of collateral sprouting
  • sodium ion transport
  • neuron migration
  • establishment of neuroblast polarity
  • protein localization in plasma membrane

Cellular Component

Where in the cell the gene product is active
  • lateral plasma membrane
  • neuron projection
  • plasma membrane
  • microtubule
  • growth cone
  • dendrite
  • nucleus
  • cytoplasm
  • sarcolemma
  • cytosol
  • filopodium
  • intercalated disc
  • axon

Molecular Function

What the gene product does at the molecular level
  • sodium channel regulator activity
  • growth factor activity
  • protein binding
  • beta-tubulin binding
  • ion channel binding
  • microtubule binding

Gene-Specific Assays for Results You Can Trust

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