Gstm1

Enables several functions, including glutathione binding activity; glutathione transferase activity; and nickel cation binding activity. Involved in several processes, including glutathione metabolic process; response to ethanol; and response to lead ion. Located in cytosol and extracellular region. Part of protein-containing complex. Used to study cholestasis. Biomarker of hypertension and liver cirrhosis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human GSTM1 (glutathione S-transferase mu 1). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gstm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Gstm1 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.