Gstm4 Gene Summary [Rat]
Predicted to enable several functions, including glutathione binding activity; glutathione transferase activity; and leukotriene-C4 synthase activity. Predicted to be involved in glutathione metabolic process and long-chain fatty acid biosynthetic process. Predicted to act upstream of or within nitrobenzene metabolic process and xenobiotic catabolic process. Predicted to be located in cytosol. Orthologous to human GSTM4 (glutathione S-transferase mu 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gstm4 |
| Official Name | glutathione S-transferase mu 4 [Source:RGD Symbol;Acc:1565825] |
| Ensembl ID | ENSRNOG00000019221 |
| Bio databases IDs | |
| Aliases | glutathione S-transferase mu 4 |
| Synonyms | glutathione S-transferase mu 4, GSTM4-4, GTM4, LOC100196943 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gstm4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- binding protein
- glutathione transferase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme binding
- protein homodimerization
- enzyme
- protein binding
- leukotriene-C4 synthase
Pathways
Biological processes and signaling networks where the Gstm4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- lung cancer
- Rett syndrome
- survival
regulates
- glutathione
- agar
- xenobiotic
- ethacrynic acid
- 1-chloro-2,4-dinitrobenzene
- p-nitrophenyl acetate
- MCTR1
- (13S,14S)-epoxymaresin
- long chain fatty acid
role in cell
- growth
- fenretinide sensitivity
- formation in
- etoposide sensitivity
- cytotoxic reaction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gstm4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty acid biosynthetic process
- nitrobenzene metabolic process
- glutathione metabolic process
- xenobiotic catabolic process
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- glutathione binding
- glutathione transferase activity
- leukotriene-C4 synthase activity
- enzyme binding