Gsr Gene Summary [Rat]
Enables several functions, including glutathione binding activity; glutathione-disulfide reductase (NADPH) activity; and nucleotide binding activity. Involved in several processes, including response to iron(III) ion; response to ischemia; and response to vitamin A. Predicted to be located in external side of plasma membrane. Predicted to be active in cytosol and mitochondrion. Used to study cataract and transient cerebral ischemia. Biomarker of several diseases, including acute kidney failure (multiple); artery disease (multiple); hemorrhagic cystitis; myoglobinuria; and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia 10 and macular degeneration. Orthologous to human GSR (glutathione-disulfide reductase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gsr |
| Official Name | glutathione-disulfide reductase [Source:RGD Symbol;Acc:621747] |
| Ensembl ID | ENSRNOG00000014915 |
| Bio databases IDs | |
| Aliases | glutathione-disulfide reductase |
| Synonyms | CNSHA10, D8Ertd238e, glutathione-disulfide reductase, Glutathione reductase, GR, Gr-1, Gred, GRX, GSRD, HEL-75, HEL-S-122m |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gsr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- electron carrier
- flavin adenine dinucleotide binding
- dihydrolipoamide dehydrogenase
- enzyme
- identical protein binding
- thioredoxin and glutathione reductase selenoprotein
- Pyridine nucleotide-disulphide oxidoreductase, dimerization domain
- mercury(II) reductase
- trypanothione-disulfide reductase
- binding protein
- NADP binding
- glutathione-disulfide reductase, plant
- Pyridine nucleotide-disulphide oxidoreductase
- glutathione-disulfide reductase
- glutathione-disulfide reductase, animal/bacterial
Pathways
Biological processes and signaling networks where the Gsr gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- metastatic brain tumor
- astrocytoma
- brainstem glioma
- oligodendroglioma
- infiltrative supratentorial astrocytoma
- activated B-cell-like diffuse large B-cell lymphoma
- glycogen storage disease type II
- breast cancer
- diffuse large B-cell lymphoma
role in cell
- survival
- morphology
- apoptosis
- sorafenib resistance
- accumulation in
- cell viability
- damage
- peroxidation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- plasma membrane extracellular face
- mitochondrial matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gsr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutathione metabolic process
- cellular response to oxidative stress
- cell redox homeostasis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- mitochondrial matrix
- mitochondrion
- external side of plasma membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- NADP binding
- flavin adenine dinucleotide binding
- electron carrier activity
- glutathione-disulfide reductase activity