Gstm1 Gene Summary [Rat]
Enables several functions, including glutathione binding activity; glutathione transferase activity; and nickel cation binding activity. Involved in several processes, including glutathione metabolic process; response to ethanol; and response to lead ion. Located in cytosol and extracellular region. Part of protein-containing complex. Used to study cholestasis. Biomarker of hypertension and liver cirrhosis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human GSTM1 (glutathione S-transferase mu 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gstm1 |
| Official Name | glutathione S-transferase mu 1 [Source:RGD Symbol;Acc:2755] |
| Ensembl ID | ENSRNOG00000029726 |
| Bio databases IDs | |
| Aliases | glutathione S-transferase mu 1 |
| Synonyms | glutathione S-transferase mu 1, glutathione S-transferase, mu 1, GSTA3, Gstb-1, Gst Gt8.7, Gstm1-1, Gstyb1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gstm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- Glutathione S-transferase, N-terminal domain
- protein kinase binding
- enzyme binding
- enzyme
- protein binding
- identical protein binding
- steroid binding
- binding protein
- glutathione transferase
- nickel ion binding
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- protein homodimerization
Pathways
Biological processes and signaling networks where the Gstm1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- spontaneous hypertension
- streptozotocin-induced diabetic nephropathy
- hearing loss
regulates
- 1-nitropyrene-9,10-oxide
- MAP3K1
- xenobiotic
- cumene hydroperoxide
- glutathione
- 1-chloro-2,4-dinitrobenzene
- trans-4-phenylbut-3-en-2-one
- ethacrynic acid
- styrene oxide
- 4-nitrobenzyl chloride
role in cell
- apoptosis
- cell death
- response by
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- nuclear fraction
- Extracellular Space
- Mitochondria
- cytoplasmic bridges
- cytosol
- mitoplasts
- detergent-soluble fraction