SEPTIN3
SEPTIN3 Gene Summary
This gene belongs to the septin family of GTPases. Members of this family are required for cytokinesis. Expression is upregulated by retinoic acid in a human teratocarcinoma cell line. The specific function of this gene has not been determined. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, May 2018]
Details
| Type | Protein Coding |
| Official Symbol | SEPTIN3 |
| Official Name | septin 3 [Source:HGNC Symbol;Acc:HGNC:10750] |
| Ensembl ID | ENSG00000100167 |
| Bio databases IDs | |
| Aliases | septin 3 |
| Synonyms | 3110018K01RIK,B530002E20Rik,bK250D10.3,Gm46500,LOC105373094,SEP3,SEPT3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- 50S ribosome-binding GTPase
- enzyme
- protein binding
- identical protein binding
- Septin
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the SEPTIN3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ESR1
- FGFR4
- SEPTIN14
- SEPTIN6
- WDTC1
- FGFR1
- SEPTIN7
- RNF8
- SEPTIN1
- ITM2B
disease
- schizophrenia
- pervasive developmental disorder
- major depression
regulated by
- IFNG
- CST5
- PCYT1A
- CEBPB
- ZIC2
- PRKG1
- MAPT
- INPP5D
regulates
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peripheral membrane fraction
- cytoskeleton
- presynaptic regions
- presynaptic membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the SEPTIN3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- protein localization
CELLULAR COMPONENT
Where in the cell the gene product is active
- microtubule cytoskeleton
- cell division site
- septin complex
- septin ring
MOLECULAR FUNCTION
What the gene product does at the molecular level
- GTP binding
- identical protein binding
- protein binding
- GTPase activity
- binding, bridging