CCL25
CCL25 Gene Summary
This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Details
| Type | Protein Coding |
| Official Symbol | CCL25 |
| Official Name | C-C motif chemokine ligand 25 [Source:HGNC Symbol;Acc:HGNC:10624] |
| Ensembl ID | ENSG00000131142 |
| Bio databases IDs | |
| Aliases | C-C motif chemokine ligand 25, Ck beta-15, thymus expressed chemokine, TECKvar |
| Synonyms | A130072A22RIK,C-C motif chemokine ligand 25,CKb15,Ck beta-15,Ck β-15,SCYA25,TECK,TECKvar |
| Species | Human, homo_sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- chemokine receptor binding
- hormone
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the CCL25 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- PF4
- ACKR4
- US4
- CCR9
- MAZ
- HNRNPD
- ZNF302
- LGALS1
- CCL5
- CCL17
disease
- renal clear cell adenocarcinoma
- renal clear cell cancer
- rheumatoid arthritis
- migraines
- pervasive developmental disorder
- systemic lupus erythematosus
regulated by
- dexamethasone
- neutrophils
- lipopolysaccharide
- TNF
- beta-estradiol
- TRIM26
- IFNG
- curdlan
- concanavalin a
- CDX2
regulates
- CASP3
- ERK1/2
- AKT
- Ca2+
- VCAM1
- F Actin
- ERM
- CXCL8
- Laminin (complex)
- P glycoprotein
role in cell
- production in
- activation in
- apoptosis
- binding in
- proliferation
- migration
- accumulation
- chemotaxis
- adhesion
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CCL25 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- chemotaxis
- inflammatory response
- immune response
- G-protein coupled receptor signaling pathway
- positive regulation of cell-matrix adhesion
- eosinophil chemotaxis
- chemokine-mediated signaling pathway
- cell surface receptor signaling pathway
- positive regulation of GTPase activity
- cell chemotaxis
- positive regulation of cell migration
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- CCR chemokine receptor binding
- CCR10 chemokine receptor binding
- chemokine activity
- chemokine receptor binding
- hormone activity