LGALS1 Gene Summary [Human]
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LGALS1 |
| Official Name | galectin 1 [Source:HGNC Symbol;Acc:HGNC:6561] |
| Ensembl ID | ENSG00000100097 |
| Bio databases IDs | |
| Aliases | galectin 1 |
| Synonyms | 14KDA LECTIN, beta GALACTOSIDE binding LECTIN precursor, betaGBP, bgbp, GAL-1, GALAPTIN, Galbp, Galectin, GALECTIN1, GBP, L14, L-14.5, Lect14, Lectin, galactose binding, soluble 1, β GALACTOSIDE binding LECTIN precursor |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LGALS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-galactoside binding domain
- laminin binding
- receptor agonist activity
- protein binding
- carbohydrate binding
- GLECT
- lactose binding
- identical protein binding
- hydrophobic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- advanced cancer
- cancer
- rheumatoid arthritis
- fibrosis
- acute inflammation
- laser induced choroidal neovascularization
- Hodgkin lymphoma
- Hodgkin disease
role in cell
- apoptosis
- activation in
- proliferation
- activity
- cellular infiltration by
- phosphorylation in
- migration
- expression in
- growth
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma membrane fraction
- nuclear fraction
- membrane fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- cell surface
- intracellular space
- Nucleus
- vacuole
- Plasma Membrane
- cytosol
- endoplasmic reticulum lumen
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LGALS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell costimulation
- plasma cell differentiation
- positive regulation of apoptotic process
- positive regulation of inflammatory response
- apoptotic process
- myoblast differentiation
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of apoptotic process
- positive regulation of viral entry into host cell
- positive regulation of dendritic cell differentiation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- lactose binding
- laminin binding