CDX2
CDX2 Gene Summary
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]
Details
| Type | Protein Coding |
| Official Symbol | CDX2 |
| Official Name | caudal type homeobox 2 [Source:HGNC Symbol;Acc:HGNC:1806] |
| Ensembl ID | ENSG00000165556 |
| Bio databases IDs | |
| Aliases | caudal type homeobox 2 |
| Synonyms | caudal type homeo box 2,CDX2/AS,CDX-3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- nucleic acid binding
- Caudal like protein activation region
- double-stranded DNA binding
- methyl-CpG binding
- protein binding
- sequence-specific DNA binding
- homeodomain
- transcription factor activity
Pathways
Biological processes and signaling networks where the CDX2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- NFKB1
- LGALS8
- Ap1
- JUN
- IPO7
- WNT3A
- XRCC5
- BTF3
- SOX2
- ZNF292
disease
- neoplasia
- growth failure
- intestinal polyposis
- neuroendocrine carcinoma
- colorectal cancer
- metaplasia
- Barrett syndrome
- ulcerative colitis
- pancreatobiliary-type ampullary adenocarcinoma
- ampullary cancer
regulated by
- beta-estradiol
- STAT3
- roscovitine
- CTNNB1
- AGS cells
- NFKB1
- HRAS
- SOX3
- THRA
- Collagen type I (complex)
regulates
- TGFB1
- RAC
- BCL2
- MYC
- CDKN1A
- IL1B
- ITGB4
- CLDN2
- NFKB2
- PTEN
role in cell
- proliferation
- activation in
- apoptosis
- phosphorylation in
- expression in
- migration
- invasion
- quantity
- growth
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- chromosome
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CDX2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- embryo development
- intestinal epithelial cell differentiation
- positive regulation of cell proliferation
- endosome to lysosome transport
- positive regulation of cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- organ morphogenesis
- labyrinthine layer development
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- anterior/posterior axis specification
- blood vessel development
- stem cell differentiation
- regulation of somitogenesis
- establishment or maintenance of epithelial cell apical/basal polarity
- cell differentiation
- somatic stem cell maintenance
- trophectodermal cell differentiation
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- transcriptional repressor complex
- chromatin
- nucleoplasm
- condensed nuclear chromosome
MOLECULAR FUNCTION
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- methyl-CpG binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity