Gpr132 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor activity. Involved in negative regulation of G2/M transition of mitotic cell cycle. Acts upstream of or within G1/S transition of mitotic cell cycle. Predicted to be located in plasma membrane. Is expressed in cerebral cortex; long bone epiphyseal plate; and thymus primordium. Used to study autoimmune disease. Orthologous to human GPR132 (G protein-coupled receptor 132). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpr132 |
| Official Name | G protein-coupled receptor 132 [Source:MGI Symbol;Acc:MGI:1890220] |
| Ensembl ID | ENSMUSG00000021298 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 132 |
| Synonyms | G2A, G protein-coupled receptor 132 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpr132 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Gpr132 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
- metastasis
- multiple sclerosis
- experimental autoimmune encephalomyelitis
- dextran sodium sulfate-induced colitis
- breast carcinoma
- demyelination
- renal neoplasm
- renal neoplasia
- colon carcinoma
- colon epithelial cancer
role in cell
- proliferation
- quantity
- production in
- morphology
- expression in
- apoptosis
- number
- growth
- chemotaxis
- condensation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endosomal fractions
- cell surface
- vesicles
- endosomal membrane
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpr132 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- G1/S transition of mitotic cell cycle
- negative regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity