Zc3h12a Gene Summary [Mouse]
Enables RNA binding activity; RNA nuclease activity; and ribosome binding activity. Involved in several processes, including negative regulation of gene expression; negative regulation of intracellular signal transduction; and regulation of apoptotic process. Located in nucleus and rough endoplasmic reticulum membrane. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Used to study primary biliary cholangitis. Human ortholog(s) of this gene implicated in hepatitis B. Orthologous to human ZC3H12A (zinc finger CCCH-type containing 12A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zc3h12a |
| Official Name | zinc finger CCCH type containing 12A [Source:MGI Symbol;Acc:MGI:2385891] |
| Ensembl ID | ENSMUSG00000042677 |
| Bio databases IDs | |
| Aliases | zinc finger CCCH type containing 12A |
| Synonyms | dJ423B22.1, FLJ23231, LOC103692471, MCPIP, MCPIP-1, Reg1, RGD1306776, zinc finger CCCH-type containing 12A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zc3h12a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-terminal conserved domain
- exoribonuclease
- UBA-like domain
- nuclease
- mRNA binding
- chromatin binding
- enzyme
- protein binding
- Zc3h12a-like Ribonuclease NYN domain
- proline rich domain
- DNA binding
- RNA binding
- RNA-binding, Nab2-type zinc finger
- mRNA 3' UTR binding
- Endoribonuclease Regnase 1/ ZC3H12 C-terminal domain
- ribonuclease
- ubiquitin-specific protease
- ribosome binding
- endoribonuclease
- PIN (PilT N terminus) domain: Superfamily
Pathways
Biological processes and signaling networks where the Zc3h12a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- papillomatosis
- epithelial neoplasia
- benign neoplasia
- cancer
- anemia
- organismal death
- atrial fibrillation
- cutaneous melanoma cancer
- skin cancer
- melanoma cancer
role in cell
- expression in
- apoptosis
- activation in
- differentiation
- production in
- number
- degradation in
- activation
- accumulation in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- GW body
- cytoplasmic ribonucleoprotein granule
- cytoplasmic mRNA processing body
- cytoskeleton
- Nucleus
- granules
- cytosol
- nucleoplasm
- rough endoplasmatic reticulum
- rough endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zc3h12a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of mRNA catabolic process
- negative regulation of interleukin-1 beta production
- positive regulation of fat cell differentiation
- negative regulation of cytokine production involved in inflammatory response
- positive regulation of angiogenesis
- inflammatory response
- negative regulation of macrophage activation
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- immune response-activating signal transduction
- apoptotic process
- defense response to virus
- negative regulation of muscle cell apoptotic process
- negative regulation of interferon-gamma production
- negative regulation of tumor necrosis factor production
- positive regulation of protein import into nucleus
- negative regulation of NF-kappaB transcription factor activity
- response to DNA damage stimulus
- cellular response to glucose starvation
- positive regulation of p38MAPK cascade
- negative regulation of nitric oxide biosynthetic process
- negative regulation of interleukin-6 production
- negative regulation of gene expression
- positive regulation of autophagy
- positive regulation of gene expression
- regulation of gene expression
- negative regulation of T-helper 17 cell differentiation
- miRNA catabolic process
- protein oligomerization
- 3'-UTR-mediated mRNA destabilization
- nervous system development
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of execution phase of apoptosis
- angiogenesis
- cellular response to tumor necrosis factor
- positive regulation of endothelial cell migration
- T cell receptor signaling pathway
- positive regulation of reactive oxygen species metabolic process
- protein deubiquitination
- positive regulation of defense response to virus by host
- cellular response to lipopolysaccharide
- negative regulation of protein phosphorylation
- positive regulation of miRNA catabolic process
- cellular response to interleukin-1
- cell differentiation
- cellular response to oxidative stress
- negative regulation of cardiac muscle contraction
- positive regulation of lipid storage
Cellular Component
Where in the cell the gene product is active
- nucleus
- rough endoplasmic reticulum membrane
- cytoskeleton
- cytoplasm
- cytoplasmic mRNA processing body
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- miRNA binding
- ribonuclease activity
- chromatin binding
- mRNA 3'-UTR binding
- endoribonuclease activity
- exoribonuclease activity
- ubiquitin-specific protease activity
- DNA binding
- RNA binding
- protein binding
- mRNA 3'-UTR AU-rich region binding
- metal ion binding
- ribosome binding
- RNA stem-loop binding
- mRNA binding