Arhgef12 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor binding activity and guanyl-nucleotide exchange factor activity. Involved in regulation of blood pressure. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and skin. Orthologous to human ARHGEF12 (Rho guanine nucleotide exchange factor 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgef12 |
| Official Name | Rho guanine nucleotide exchange factor (GEF) 12 [Source:MGI Symbol;Acc:MGI:1916882] |
| Ensembl ID | ENSMUSG00000059495 |
| Bio databases IDs | |
| Aliases | Rho guanine nucleotide exchange factor (GEF) 12 |
| Synonyms | 2310014B11RIK, AU019857, LARG, LARG RhoGEF, mKIAA0382, PRO2792, Rho guanine nucleotide exchange factor 12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgef12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- Regulator of G protein signalling-like domain
- G-protein-coupled receptor binding
- nuclear localization sequence
- canonical PDZ domain
- Regulator of G protein signaling (RGS) domain superfamily
- protein binding
- Pleckstrin homology-like domain
- PDZ domain
- RhoGEF domain
- RhoGEF
- guanyl-nucleotide exchange factor
- PH domain
- cpPDZ_Deg_HtrA-like
- PDZ binding motif
- Dbl homology domain
- cpPDZ_RseP_YlbL-like
Pathways
Biological processes and signaling networks where the Arhgef12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- angina pectoris
- Klinefelter syndrome
- lung adenocarcinoma
- lung adenocarcinoma formation
- open-angle glaucoma
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- organismal death
- coronary artery disease
role in cell
- migration
- proliferation
- activation in
- formation
- endothelial barrier function
- abnormal morphology
- transactivation in
- disorganization
- protrusion/retraction in
- disorganization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
- cellular protrusions
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgef12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- regulation of small GTPase mediated signal transduction
- Rho protein signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor binding
- protein binding
- GTPase activator activity
- guanyl-nucleotide exchange factor activity