Ttl Gene Summary [Mouse]
Enables tubulin-tyrosine ligase activity. Acts upstream of or within microtubule cytoskeleton organization and regulation of axon extension. Predicted to be located in microtubule. Predicted to be active in spindle microtubule. Is expressed in musculature and nervous system. Orthologous to human TTL (tubulin tyrosine ligase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ttl |
| Official Name | tubulin tyrosine ligase [Source:MGI Symbol;Acc:MGI:1916987] |
| Ensembl ID | ENSMUSG00000027394 |
| Bio databases IDs | |
| Aliases | tubulin tyrosine ligase |
| Synonyms | 2410003M22RIK, 2700049H19RIK, AI848570, tubulin tyrosine ligase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ttl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- enzyme
- tubulin-tyrosine ligase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- spindle fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ttl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of axon extension
- regulation of metaphase plate congression
- microtubule cytoskeleton organization
- post-translational protein modification
- positive regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- spindle microtubule
Molecular Function
What the gene product does at the molecular level
- ATP binding
- tubulin-tyrosine ligase activity