Marveld2 Gene Summary [Mouse]
Acts upstream of or within cell-cell junction organization and sensory perception of sound. Located in Schmidt-Lanterman incisure; paranodal junction; and tight junction. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Used to study autosomal recessive nonsyndromic deafness 49. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 49. Orthologous to human MARVELD2 (MARVEL domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Marveld2 |
| Official Name | MARVEL (membrane-associating) domain containing 2 [Source:MGI Symbol;Acc:MGI:2446166] |
| Ensembl ID | ENSMUSG00000021636 |
| Bio databases IDs | |
| Aliases | MARVEL (membrane-associating) domain containing 2 |
| Synonyms | DFNB49, MARVD2, MARVEL domain containing 2, MARVEL (membrane-associating) domain containing 2, MRVLDC2, Tric, Trica, Tricb, Tricc |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Marveld2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Membrane-associating domain
- protein binding
- Occludin homology domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive deafness type 49
- preeclampsia
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
- hearing loss
- familial nonsyndromic hearing impairment
- absent pinna reflex
- autosomal recessive deafness
- papillary thyroid carcinoma
role in cell
- organization
- degeneration
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- Cytoplasm
- intercellular junctions
- apical membrane
- basolateral membrane
- paranodal junctions
- Schmidt-Lanterman incisures
- cytoplasmic vesicles
- tight junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Marveld2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- tight junction assembly
- establishment of endothelial barrier
- cell-cell junction organization
Cellular Component
Where in the cell the gene product is active
- occluding junction
- tight junction
- cytoplasm
- paranodal junction
- Schmidt-Lanterman incisure
- cytoplasmic vesicle
- cell junction
- basolateral plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding