TTL Gene Summary [Human]
TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | TTL |
| Official Name | tubulin tyrosine ligase [Source:HGNC Symbol;Acc:HGNC:21586] |
| Ensembl ID | ENSG00000114999 |
| Bio databases IDs | |
| Aliases | tubulin tyrosine ligase |
| Synonyms | 2410003M22RIK, 2700049H19RIK, AI848570, tubulin tyrosine ligase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TTL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- enzyme
- tubulin-tyrosine ligase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- spindle fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TTL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of axon extension
- regulation of metaphase plate congression
- microtubule cytoskeleton organization
- post-translational protein modification
- positive regulation of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- spindle microtubule
Molecular Function
What the gene product does at the molecular level
- ATP binding
- tubulin-tyrosine ligase activity