Aldh9a1 Gene Summary [Rat]
Enables several functions, including NAD binding activity; identical protein binding activity; and oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. Involved in kidney development and liver development. Located in cytoplasm. Orthologous to human ALDH9A1 (aldehyde dehydrogenase 9 family member A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aldh9a1 |
| Official Name | aldehyde dehydrogenase 9 family, member A1 [Source:RGD Symbol;Acc:68409] |
| Ensembl ID | ENSRNOG00000004027 |
| Bio databases IDs | |
| Aliases | aldehyde dehydrogenase 9 family, member A1 |
| Synonyms | 4-Trimethylaminobutyraldehyde Dehydrogenase 9a, Abaldh, aldehyde dehydrogenase 9 family member A1, aldehyde dehydrogenase 9 family, member A1, aldehyde dehydrogenase 9, subfamily A1, Aldh3a9, ALDH4, ALDH7, ALDH9, E3, ESTM40, LOC100910278, TMABA-DH, TMABALDH |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aldh9a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aldehyde dehydrogenase family
- 4-trimethylammoniobutyraldehyde dehydrogenase
- aminobutyraldehyde dehydrogenase
- enzyme
- identical protein binding
- formaldehyde dehydrogenase
- delta-1-pyrroline-5-carboxylate dehydrogenase (PutA C-terminal domain)
- NAD(P)+-dependent aldehyde dehydrogenase superfamily
- NAD or NADH binding
- betaine-aldehyde dehydrogenase
- binding protein
- aldehyde dehydrogenase (NAD)
- delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative
- methylmalonic acid semialdehyde dehydrogenase
- aldehyde or oxo group:NAD or NADP oxidoreductase
Pathways
Biological processes and signaling networks where the Aldh9a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- COVID-19
- epithelial cancer
- obesity
- lymphomagenesis
- lymphoma
regulates
- carnitine
- aldehyde
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aldh9a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homotetramerization
- cellular aldehyde metabolic process
- carnitine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- aldehyde dehydrogenase (NAD) activity
- glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
- aminobutyraldehyde dehydrogenase activity
- small molecule binding
- 4-trimethylammoniobutyraldehyde dehydrogenase activity
- formaldehyde dehydrogenase activity