ALDH9A1 Gene Summary [Human]
This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ALDH9A1 |
| Official Name | aldehyde dehydrogenase 9 family member A1 [Source:HGNC Symbol;Acc:HGNC:412] |
| Ensembl ID | ENSG00000143149 |
| Bio databases IDs | |
| Aliases | aldehyde dehydrogenase 9 family member A1 |
| Synonyms | 4-Trimethylaminobutyraldehyde Dehydrogenase 9a, Abaldh, aldehyde dehydrogenase 9 family member A1, aldehyde dehydrogenase 9 family, member A1, aldehyde dehydrogenase 9, subfamily A1, Aldh3a9, ALDH4, ALDH7, ALDH9, E3, ESTM40, LOC100910278, TMABA-DH, TMABALDH |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ALDH9A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aldehyde dehydrogenase family
- 4-trimethylammoniobutyraldehyde dehydrogenase
- aminobutyraldehyde dehydrogenase
- enzyme
- identical protein binding
- formaldehyde dehydrogenase
- delta-1-pyrroline-5-carboxylate dehydrogenase (PutA C-terminal domain)
- NAD(P)+-dependent aldehyde dehydrogenase superfamily
- NAD or NADH binding
- betaine-aldehyde dehydrogenase
- binding protein
- aldehyde dehydrogenase (NAD)
- delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative
- methylmalonic acid semialdehyde dehydrogenase
- aldehyde or oxo group:NAD or NADP oxidoreductase
Pathways
Biological processes and signaling networks where the ALDH9A1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- COVID-19
- epithelial cancer
- obesity
- lymphomagenesis
- lymphoma
regulates
- carnitine
- aldehyde
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ALDH9A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homotetramerization
- cellular aldehyde metabolic process
- carnitine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- aldehyde dehydrogenase (NAD) activity
- glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
- aminobutyraldehyde dehydrogenase activity
- small molecule binding
- 4-trimethylammoniobutyraldehyde dehydrogenase activity
- formaldehyde dehydrogenase activity