Dffb Gene Summary [Rat]
Enables DNA nuclease activity. Involved in apoptotic DNA fragmentation. Predicted to be located in chromatin; cytosol; and nuclear lumen. Predicted to be part of protein-containing complex. Biomarker of transient cerebral ischemia. Orthologous to human DFFB (DNA fragmentation factor subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dffb |
| Official Name | DNA fragmentation factor subunit beta [Source:RGD Symbol;Acc:620335] |
| Ensembl ID | ENSRNOG00000025030 |
| Bio databases IDs | |
| Aliases | DNA fragmentation factor subunit beta |
| Synonyms | 5730477D02Rik, CAD, caspase-activated DNase, CPAN, DFF2, DFF-40, Didff, DNA fragmentation factor, beta subunit, DNA fragmentation factor subunit beta, DNA fragmentation factor subunit β, DNA fragmentation factor, β subunit |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dffb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNase
- nuclease
- CIDE-N domain
- enzyme binding
- active site
- CIDE_N
- protein domain specific binding
- enzyme
- protein binding
- identical protein binding
- DNA binding
- DNA fragmentation factor 40 kDa
Pathways
Biological processes and signaling networks where the Dffb gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- anemia
- interstitial fibrosis
- hypoplasia
- cardiac hypertrophy
- myocardial hypertrophy
- heart disease
- perivascular fibrosis
- colon carcinoma
- colon epithelial cancer
role in cell
- apoptosis
- phosphorylation in
- cell death
- degradation in
- transformation
- condensation
- release
- differentiation
- cross-sectional area
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- perinuclear region
- cytosol
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dffb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA catabolic process
- apoptotic DNA fragmentation
- apoptotic chromosome condensation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- macromolecular complex
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein domain specific binding
- identical protein binding
- protein binding
- deoxyribonuclease activity
- endodeoxyribonuclease activity
- enzyme binding