Vps28 Gene Summary [Rat]
Predicted to enable ubiquitin binding activity. Predicted to be involved in positive regulation of ubiquitin-dependent endocytosis; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; and regulation of protein metabolic process. Located in cytosol. Orthologous to human VPS28 (VPS28 subunit of ESCRT-I). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vps28 |
| Official Name | VPS28 subunit of ESCRT-I [Source:RGD Symbol;Acc:1306537] |
| Ensembl ID | ENSRNOG00000014633 |
| Bio databases IDs | |
| Aliases | VPS28 subunit of ESCRT-I |
| Synonyms | 1110014J03Rik, CIIA, D730005C08Rik, vacuolar protein sorting 28, VPS28 subunit of ESCRT-I, VPS protein HOMOLOG |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vps28 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- VPS28 protein
- ubiquitin binding
- protein binding
- transporter
Pathways
Biological processes and signaling networks where the Vps28 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
role in cell
- growth
- apoptosis
- activation in
- cell death
- colony formation
- binding in
- degradation in
- migration
- assembly
- growth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- endosomes
- cytosol
- endosomal membrane
- early endosomes
- exosomes
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vps28 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- membrane fission
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- positive regulation of protein catabolic process
- positive regulation of ubiquitin-dependent endocytosis
- negative regulation of protein ubiquitination
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- early endosome
- extracellular vesicular exosome
- endosome
- cytoplasm
- ESCRT I complex
- cytosol
- endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding