Nes Gene Summary [Rat]
Enables CCR5 chemokine receptor binding activity. Involved in several processes, including positive regulation of intermediate filament depolymerization; positive regulation of neural precursor cell proliferation; and response to ionizing radiation. Located in intermediate filament. Biomarker of acute kidney failure; brain infarction; brain ischemia; and nephrosis. Orthologous to human NES (nestin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nes |
| Official Name | nestin [Source:RGD Symbol;Acc:3162] |
| Ensembl ID | ENSRNOG00000018681 |
| Bio databases IDs | |
| Aliases | nestin |
| Synonyms | ESTM46, Ifaprc2, LOC100910255, Marc2, Nbla00170, Nestin, Nestin1, RC2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nes often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- intermediate filament binding
- exonuclease SbcC
- CCR chemokine receptor binding
- protein binding
- Intermediate filament protein
Pathways
Biological processes and signaling networks where the Nes gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- glioblastoma
- neoplasia
- glioblastoma cancer
- glioma formation
- central nervous system cancer
- head and neck neoplasia
- brain cancer
role in cell
- proliferation
- phosphorylation in
- apoptosis
- survival
- growth
- cell viability
- number
- G2/M phase transition
- migration
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intermediate filament cytoskeleton
- Cytoplasm
- cell surface
- Mitochondria
- intermediate filaments
- myofilaments
- sarcoplasm
- axoplasm
- neuromuscular junctions
- nerve ending
- cellular protrusions
- membrane processes
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nes gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryonic camera-type eye development
- brain development
- negative regulation of protein binding
- cell projection morphogenesis
- negative regulation of neuron apoptotic process
- positive regulation of intermediate filament depolymerization
- G2/M transition of mitotic cell cycle
- central nervous system development
- negative regulation of catalytic activity
- stem cell proliferation
- positive regulation of neural precursor cell proliferation
- neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- intermediate filament cytoskeleton
- cytoplasm
- intermediate filament
Molecular Function
What the gene product does at the molecular level
- protein binding
- intermediate filament binding
- CCR5 chemokine receptor binding