Clta Gene Summary [Rat]
Enables GTPase binding activity and peptide binding activity. Involved in synaptic vesicle endocytosis. Located in clathrin-coated pit and clathrin-coated vesicle. Part of clathrin coat. Is active in postsynaptic endocytic zone; presynaptic endocytic zone membrane; and synaptic vesicle membrane. Orthologous to human CLTA (clathrin light chain A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clta |
| Official Name | clathrin, light chain A [Source:RGD Symbol;Acc:70919] |
| Ensembl ID | ENSRNOG00000014635 |
| Bio databases IDs | |
| Aliases | clathrin, light chain A |
| Synonyms | AV026556, CLATHRIN LIGHT CHAIN-A, clathrin, light chain A, CLTA2, LCA, LCA1, LCA2, LCA3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Clta often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- conserved domain
- peptide binding
- binding protein
- Hsc70-binding domain
- enzyme binding
- clathrin binding
- Clathrin light chain
- protein binding
- calcium binding loop
- Clathrin HC binding domain
Pathways
Biological processes and signaling networks where the Clta gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- motor dysfunction or movement disorder
- bipolar disorder
- Parkinson disease
- infection by HIV-1
regulates
- LDLR
- neurotransmitter
role in cell
- number
- quantity
- endocytosis
- growth
- assembly
- abnormal quantity
- replenishment in
- synaptic transmission in
- replenishment
- recycling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- synaptic vesicle membrane
- glutaminergic synapse
- endocytic vesicle membrane
- intracellular membrane-bounded organelle
- cell surface
- perinuclear region
- cellular membrane
- endosomes
- lysosome
- Golgi Apparatus
- cytosol
- synaptic membrane
- trans Golgi network
- lysosome membrane
- endosomal membrane
- cytoplasmic vesicles
- clathrin-coated pits
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Clta gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- clathrin-mediated endocytosis
- clathrin coat assembly
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- endolysosome membrane
- clathrin coat of trans-Golgi network vesicle
- clathrin-coated endocytic vesicle
- plasma membrane
- clathrin coat
- membrane
- spindle
- clathrin coat of coated pit
- cytoplasmic vesicle
- cytosol
- synaptic vesicle membrane
- clathrin vesicle coat
- clathrin complex
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- clathrin heavy chain binding
- protein binding
- GTPase binding
- structural molecule activity
- peptide binding