Oxct1 Gene Summary [Rat]
Enables identical protein binding activity and succinyl-CoA:3-oxo-acid CoA-transferase activity. Involved in several processes, including positive regulation of insulin secretion involved in cellular response to glucose stimulus; response to activity; and response to ethanol. Predicted to be active in mitochondrion. Biomarker of obesity and type 2 diabetes mellitus. Orthologous to human OXCT1 (3-oxoacid CoA-transferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Oxct1 |
| Official Name | 3-oxoacid CoA transferase 1 [Source:RGD Symbol;Acc:1584008] |
| Ensembl ID | ENSRNOG00000043094 |
| Bio databases IDs | |
| Aliases | 3-oxoacid CoA transferase 1 |
| Synonyms | 2610008O03Rik, 3-Oxoacid coa transferase, 3-oxoacid CoA-transferase 1, LOC100359544, LOC678860, LOC690109, LOC690163, OXCT, Oxct1 (predicted), Oxct2a, SCOT, Scot-s, Succinyl coa:3-ketoacid coa transferase, Succinyl COA:3-OXOACID COA TRANSFERASE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Oxct1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SugarP_isomerase
- 3-oxoacid CoA-transferase
- protein homodimerization
- enzyme
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- schizophrenia
- facioscapulohumeral muscular dystrophy
- succinyl-coa acetoacetate transferase deficiency
- ketoaciduria
regulates
- ketone body
- LACTB
- ketone
role in cell
- growth
- gemcitabine resistance
- succinylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Oxct1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ketone catabolic process
- ketone body catabolic process
- cellular ketone body metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- 3-oxoacid CoA-transferase activity