Hspb6 Gene Summary [Rat]
Enables protein homodimerization activity and protein kinase binding activity. Involved in negative regulation of cardiac muscle cell apoptotic process. Predicted to be located in several cellular components, including cytosol; mitochondrion; and nuclear speck. Predicted to be active in cytoplasm and nucleus. Orthologous to human HSPB6 (heat shock protein family B (small) member 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hspb6 |
| Official Name | heat shock protein family B (small) member 6 [Source:RGD Symbol;Acc:621554] |
| Ensembl ID | ENSRNOG00000020922 |
| Bio databases IDs | |
| Aliases | heat shock protein family B (small) member 6 |
| Synonyms | FLJ32389, Gm479, heat shock protein, alpha-crystallin-related, B6, heat shock protein family B (small) member 6, heat shock protein, α-crystallin-related, B6, HEL55, Hsp20, p20, PPP1R91 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hspb6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta strand or sheet
- protein kinase binding
- alpha-crystallin Hsps/p23-like
- protein homodimerization
- Hsp20/alpha crystallin family
- protein binding
- chaperone binding
- Alpha crystallin A chain, N terminal
Pathways
Biological processes and signaling networks where the Hspb6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell lung cancer
- neoplasia
- lung squamous cell carcinoma
- osteosarcoma
- urothelial bladder carcinoma
- transitional cell bladder cancer
- thyroid carcinoma
- epithelial thyroid cancer
- osteoarthritis
- prostate cancer
role in cell
- production in
- proliferation
- migration
- expression in
- growth
- invasiveness
- apoptosis
- cell death
- activation in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Nucleus
- Mitochondria
- cytosol
- nuclear speckles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hspb6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to heat
- negative regulation of apoptotic process
- chaperone-mediated protein folding
- protein refolding
- positive regulation of angiogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- mitochondrion
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding involved in protein folding
- chaperone binding
- unfolded protein binding
- structural constituent of eye lens