Ppp1ca Gene Summary [Rat]
Enables phosphoprotein phosphatase activity; protein phosphatase 1 binding activity; and ribonucleoprotein complex binding activity. Involved in protein dephosphorylation; regulation of glycogen metabolic process; and response to lead ion. Located in dendritic spine; glycogen granule; and perikaryon. Part of protein phosphatase type 1 complex. Is active in glutamatergic synapse; postsynapse; and presynapse. Orthologous to human PPP1CA (protein phosphatase 1 catalytic subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp1ca |
| Official Name | protein phosphatase 1 catalytic subunit alpha [Source:RGD Symbol;Acc:3375] |
| Ensembl ID | ENSRNOG00000018708 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1 catalytic subunit alpha |
| Synonyms | dism2, PP-1A, PP1 alpha, Pp-1c, PP1C alpha, PP1C α, PP1 α, PP1 α C, PPP1A, Ppp1c, Protein Phosphatase 1, protein phosphatase 1 catalytic subunit alpha, protein phosphatase 1 catalytic subunit α, Ser/Thr Phosphatase Type1 alpha, Ser/Thr Phosphatase Type1 α |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppp1ca often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Serine-threonine protein phosphatase N-terminal domain
- catalytic domain
- phosphoprotein phosphatase
- protein serine/threonine phosphatase
- cell adhesion molecule binding
- iron ion binding
- metallophosphatase superfamily, metallophosphatase domain
- protein binding
- transition metal ion binding
- Calcineurin-like phosphoesterase
- CTD phosphatase
- protein phosphatase 1 binding
- binding protein
- protein phosphatase
- ribonucleoprotein binding
- phosphatase
- cadherin binding
- Protein phosphatase 2A homologues, catalytic domain
Pathways
Biological processes and signaling networks where the Ppp1ca gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Breast Cancer Regulation by Stathmin1
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- EIF2 Signaling
- ERK/MAPK Signaling
- HIPPO signaling
- Insulin Receptor Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Protein Kinase A Signaling
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic lymphocytic leukemia
- cutaneous melanoma cancer
- persistent atrial fibrillation
- cardiomyopathy
- pancreatic cancer
- dilated cardiomyopathy
- systemic lupus erythematosus
- chronic epilepsy
role in cell
- production in
- migration
- expression in
- growth
- phosphorylation in
- apoptosis
- adhesion
- cell death
- activation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- high-density microsomal fractions
- soluble fraction
- postsynaptic density (PSD) fractions
- glutaminergic synapse
- presynaptic regions
- cell periphery
- postsynaptic region
- focal adhesions
- cell cortex
- Nucleus
- Plasma Membrane
- centrosome
- midbody
- cytosol
- nuclear foci
- nucleoplasm
- nucleoli
- dendritic spines
- dendritic spine neck
- dendritic spine head
- synaptosomes
- kinetochores
- telomeres
- perikaryon
- postsynaptic density
- axon terminals
- dendritic shafts
- cell-cell adherens junctions
- cytoskeletal fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppp1ca gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
- protein dephosphorylation
- regulation of glycogen catabolic process
- branching morphogenesis of a tube
- regulation of translational initiation
- regulation of circadian rhythm
- telomere maintenance in response to DNA damage
- cell division
- circadian regulation of gene expression
- glycogen metabolic process
- regulation of glycogen biosynthetic process
- regulation of canonical Wnt receptor signaling pathway
- entrainment of circadian clock by photoperiod
- response to lead ion
- dephosphorylation
- lung development
Cellular Component
Where in the cell the gene product is active
- glycogen granule
- perikaryon
- nucleolus
- plasma membrane
- nucleoplasm
- nucleus
- chromosome, telomeric region
- adherens junction
- extracellular vesicular exosome
- cytoplasm
- dendritic spine
- cytosol
- PTW/PP1 phosphatase complex
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- phosphoprotein phosphatase activity
- protein binding
- metal ion binding
- ribonucleoprotein complex binding
- phosphatase activity
- protein phosphatase 1 binding
- myosin phosphatase activity