Psmb10 Gene Summary [Mouse]
Predicted to enable endopeptidase activity. Acts upstream of or within T cell proliferation and cell morphogenesis. Part of proteasome core complex and spermatoproteasome complex. Is expressed in several structures, including adrenal gland; cerebral cortex; genitourinary system; hemolymphoid system; and liver. Human ortholog(s) of this gene implicated in immunodeficiency 121 and proteosome-associated autoinflammatory syndrome 5. Orthologous to human PSMB10 (proteasome 20S subunit beta 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Psmb10 |
| Official Name | proteasome (prosome, macropain) subunit, beta type 10 [Source:MGI Symbol;Acc:MGI:1096380] |
| Ensembl ID | ENSMUSG00000031897 |
| Bio databases IDs | |
| Aliases | proteasome (prosome, macropain) subunit, beta type 10 |
| Synonyms | beta2i, beta 2I IMMUNOPROTEASOME, IMD121, LMP10, MECL1, PRAAS5, proteasome 20S subunit beta 10, proteasome 20S subunit β 10, Proteasome MECl-1, proteasome (prosome, macropain) subunit, beta type 10, proteasome (prosome, macropain) subunit, β type 10, proteasome subunit Z, β 2I IMMUNOPROTEASOME |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psmb10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ntn_hydrolase
- proteasome endopeptidase complex
- peptidase
- protein binding
- Proteasome subunit
Pathways
Biological processes and signaling networks where the Psmb10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- relapsed multiple myeloma
- light chain only multiple myeloma
- plasma cell myeloma
- tuberculosis
- persistent atrial fibrillation
- refractory multiple myeloma
- psoriasis
- Waldenström macroglobulinemia
- smoldering myeloma
- symptomatic multiple myeloma
phenotypes
- abnormal CD8-positive alpha-beta cytotoxic T cell morphology
- abnormal T cell activation
- abnormal cytotoxic T cell physiology
- absent lymph nodes
- absent spleen white pulp
- absent subcutaneous adipose tissue
- alopecia
- athymia
- decreased B cell number
- decreased CD4-positive alpha beta T cell number
- decreased CD8-positive alpha-beta T cell number
- decreased NK cell number
- decreased T cell number
- decreased T cell proliferation
- decreased body size
- decreased immunoglobulin level
- decreased interferon-gamma secretion
- decreased leukocyte cell number
- decreased spleen red pulp amount
- hyperkeratosis
- increased circulating interleukin-1 level
- increased circulating interleukin-6 level
- increased circulating tumor necrosis factor level
- increased granulocyte number
- increased inflammatory response
- increased susceptibility to bacterial infection induced morbidity/mortality
- premature death
- skin inflammation
role in cell
- expression in
- apoptosis
- growth
- quantity
- proliferation
- abnormal morphology
- function
- number
- repression in
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- clastosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psmb10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- cell morphogenesis
- T cell proliferation
- humoral immune response
Cellular Component
Where in the cell the gene product is active
- nucleus
- proteasome core complex
- cytosol
- proteasome complex
- proteasome core complex, beta-subunit complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- endopeptidase activity
- threonine-type endopeptidase activity