Crx Gene Summary [Mouse]
Enables several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; chromatin binding activity; and nuclear receptor binding activity. Involved in regulation of DNA-templated transcription. Acts upstream of or within positive regulation of transcription by RNA polymerase II and retina development in camera-type eye. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including face; liver; lung; nervous system; and retina. Used to study Leber congenital amaurosis 7 and cone-rod dystrophy 2. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 7 and cone-rod dystrophy 2. Orthologous to human CRX (cone-rod homeobox). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crx |
| Official Name | cone-rod homeobox [Source:MGI Symbol;Acc:MGI:1194883] |
| Ensembl ID | ENSMUSG00000041578 |
| Bio databases IDs | |
| Aliases | cone-rod homeobox |
| Synonyms | cone-rod homeobox, CORD2, CRD, Crx1, LCA7, OTX3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- ligand-dependent nuclear receptor interactor
- DNA binding domain
- nucleic acid binding
- LRR-domain binding
- transcription factor binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- Otx1 transcription factor
- homeodomain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal dominant cone-rod dystrophy
- Leber congenital amaurosis
- retinal dystrophy
- cone-rod dystrophy type 2
- retinitis pigmentosa
- fundus flavimaculatus
- leber congenital amaurosis type 7
- group 3 medulloblastoma
- brain cancer
- autosomal dominant retinitis pigmentosa
role in cell
- expression in
- growth
- formation
- abnormal morphology
- quantity
- degeneration
- function
- transactivation in
- lack
- electrophysiology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nervous system development
- cell differentiation
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- visual perception
- organ morphogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- ligand-dependent nuclear receptor binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
- leucine zipper domain binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity