Uqcrc1 Gene Summary [Mouse]

Predicted to enable ubiquitin protein ligase binding activity. Acts upstream of or within mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Part of respiratory chain complex III. Is active in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; central nervous system; metanephros; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human UQCRC1 (ubiquinol-cytochrome c reductase core protein 1). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Uqcrc1
Official Name
ubiquinol-cytochrome c reductase core protein 1 [Source:MGI Symbol;Acc:MGI:107876]
Ensembl ID
ENSMUSG00000025651
Bio databases IDs NCBI: 22273 Ensembl: ENSMUSG00000025651
Aliases ubiquinol-cytochrome c reductase core protein 1
Synonyms 1110032G10Rik, COR1, D3S3191, PKNPY, QCR1, Ubiquinol cytochrome c reductase 1, Ubiquinol Cytochrome C Reductase Core 1, ubiquinol-cytochrome c reductase core protein 1, UQCR1
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Uqcrc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • ubiquitin protein ligase binding
  • ubiquinol-cytochrome-c reductase
  • binding protein
  • enzyme
  • protein binding
  • Insulinase (Peptidase family M16)
  • Peptidase M16 inactive domain

Pathways

Biological processes and signaling networks where the Uqcrc1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • insulin resistance
  • liver cancer
  • epithelial cancer
  • Huntington disease
  • Alzheimer disease
  • parkinsonism with polyneuropathy
  • hepatitis B virus-related hepatocellular carcinoma
  • idiopathic scoliosis
  • hypertrophic cardiomyopathy
  • hepatitis C virus-related hepatocellular carcinoma
regulated by
regulates
  • reactive oxygen species
  • Cytochrome bc1
role in cell
  • apoptosis
  • production in
  • survival
  • respiration
  • quantity

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • myelin enriched fraction
  • pH resistant lipid raft fraction
  • detergent resistant lipid raft fraction
  • cellular membrane
  • Nucleus
  • Mitochondria
  • myofilaments
  • mitochondrial inner membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Uqcrc1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • oxidative phosphorylation
  • response to alkaloid
  • cellular respiration
  • response to activity
  • mitochondrial electron transport, ubiquinol to cytochrome c
  • aerobic respiration

Cellular Component

Where in the cell the gene product is active
  • mitochondrial respiratory chain
  • mitochondrion
  • mitochondrial respiratory chain complex III
  • mitochondrial inner membrane

Molecular Function

What the gene product does at the molecular level
  • ubiquitin protein ligase binding
  • protein binding
  • ubiquinol-cytochrome-c reductase activity
  • metal ion binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.