ALDOA Gene Summary

This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Sep 2017]

Details

Type
Retained Intron
Official Symbol
ALDOA
Official Name
aldolase, fructose-bisphosphate A [Source:HGNC Symbol;Acc:HGNC:414]
Ensembl ID
ENSG00000149925
Bio databases IDs NCBI: 226 Ensembl: ENSG00000149925
Aliases aldolase, fructose-bisphosphate A
Synonyms
ALDA,Aldo-1,Aldol A,ALDOLASE,Aldolase 1,Aldolase 1a,Aldolase A,aldolase A, fructose-bisphosphate,aldolase, fructose-bisphosphate A,Alfa,Gm15676,GSD12,HEL-S-87p,RNALDOG5
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • monosaccharide binding
  • cytoskeletal protein binding
  • protease binding
  • TIM-like beta/alpha barrel domains
  • tubulin binding
  • Fructose-bisphosphate aldolase class-I
  • actin binding
  • fructose-bisphosphate aldolase
  • enzyme
  • protein binding
  • identical protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • cervical cancer
  • neoplasia
  • metastasis
  • Alzheimer disease
  • rheumatoid arthritis
  • lung adenocarcinoma
  • lung adenocarcinoma formation
  • hepatocellular carcinoma
  • organismal death
  • papillary thyroid carcinoma
regulated by
regulates
  • reactive oxygen species
  • glutathione peroxidase
  • SOD
  • p38 MAPK
  • malondialdehyde
  • ERK1/2
  • lactic acid
  • adenosine triphosphate
  • D-fructose
  • SNAI2
role in cell
  • migration
  • apoptosis
  • proliferation
  • formation
  • phosphorylation in
  • formation in
  • survival
  • binding
  • organization
  • invasion by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • myelin enriched fraction
  • detergent resistant lipid raft fraction
  • heterochromatin
  • secretory granule lumen
  • ficolin-1-rich granule lumen
  • cell surface
  • Extracellular Space
  • cell periphery
  • organelle lumens
  • cellular membrane
  • actin cytoskeleton
  • Nucleus
  • Plasma Membrane
  • cytosol
  • alpha granules
  • sperm fibrous sheath
  • sperm head
  • cytoplasmic droplets
  • I band
  • Z line
  • exosomes
  • plasma

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the ALDOA gene, providing context for its role in the cell.

biological PROCESS

Functions and activities the gene product is involved in
  • regulation of cell shape
  • muscle cell homeostasis
  • binding of sperm to zona pellucida
  • protein homotetramerization
  • glycolysis
  • actin filament organization
  • fructose metabolic process
  • striated muscle contraction
  • ATP biosynthetic process
  • fructose 1,6-bisphosphate metabolic process

cellular COMPONENT

Where in the cell the gene product is active
  • platelet alpha granule lumen
  • nucleus
  • extracellular space
  • extracellular vesicular exosome
  • membrane
  • actin cytoskeleton
  • cytosol
  • I band
  • secretory granule lumen
  • M band
  • extracellular region

molecular FUNCTION

What the gene product does at the molecular level
  • tubulin binding
  • identical protein binding
  • fructose binding
  • protein binding
  • RNA binding
  • actin binding
  • cadherin binding
  • cytoskeletal protein binding
  • fructose-bisphosphate aldolase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.