Aldoa Gene Summary [Mouse]
Enables fructose-bisphosphate aldolase activity and protease binding activity. Involved in canonical glycolysis and positive regulation of cell migration. Located in Z disc; plasma membrane; and sperm fibrous sheath. Part of protein-containing complex. Is active in cytosol. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human ALDOA (aldolase, fructose-bisphosphate A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aldoa |
| Official Name | aldolase A, fructose-bisphosphate [Source:MGI Symbol;Acc:MGI:87994] |
| Ensembl ID | ENSMUSG00000030695 |
| Bio databases IDs | |
| Aliases | aldolase A, fructose-bisphosphate |
| Synonyms | ALDA, Aldo-1, Aldol A, ALDOLASE, Aldolase 1, Aldolase 1a, Aldolase A, aldolase A, fructose-bisphosphate, aldolase, fructose-bisphosphate A, Alfa, Gm15676, GSD12, HEL-S-87p, RNALDOG5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aldoa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- monosaccharide binding
- cytoskeletal protein binding
- protease binding
- TIM-like beta/alpha barrel domains
- tubulin binding
- Fructose-bisphosphate aldolase class-I
- actin binding
- fructose-bisphosphate aldolase
- enzyme
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cervical cancer
- neoplasia
- metastasis
- Alzheimer disease
- rheumatoid arthritis
- lung adenocarcinoma
- lung adenocarcinoma formation
- hepatocellular carcinoma
- organismal death
- papillary thyroid carcinoma
regulates
- reactive oxygen species
- glutathione peroxidase
- SOD
- p38 MAPK
- malondialdehyde
- ERK1/2
- lactic acid
- adenosine triphosphate
- D-fructose
- SNAI2
role in cell
- migration
- apoptosis
- proliferation
- formation
- phosphorylation in
- formation in
- survival
- binding
- organization
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- detergent resistant lipid raft fraction
- heterochromatin
- secretory granule lumen
- ficolin-1-rich granule lumen
- cell surface
- Extracellular Space
- cell periphery
- organelle lumens
- cellular membrane
- actin cytoskeleton
- Nucleus
- Plasma Membrane
- cytosol
- alpha granules
- sperm fibrous sheath
- sperm head
- cytoplasmic droplets
- I band
- Z line
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aldoa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- muscle cell homeostasis
- binding of sperm to zona pellucida
- protein homotetramerization
- glycolysis
- actin filament organization
- fructose metabolic process
- striated muscle contraction
- ATP biosynthetic process
- fructose 1,6-bisphosphate metabolic process
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- nucleus
- extracellular space
- extracellular vesicular exosome
- membrane
- actin cytoskeleton
- cytosol
- I band
- secretory granule lumen
- M band
- extracellular region
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- identical protein binding
- fructose binding
- protein binding
- RNA binding
- actin binding
- cadherin binding
- cytoskeletal protein binding
- fructose-bisphosphate aldolase activity