Jup Gene Summary [Mouse]
Enables alpha-catenin binding activity. Acts upstream of or within cell-cell adhesion; desmosome assembly; and skin development. Located in several cellular components, including Z disc; adherens junction; and intermediate filament. Part of catenin complex. Is active in cornified envelope. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Used to study arrhythmogenic right ventricular dysplasia 12 and epidermolytic hyperkeratosis. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); palmoplantar keratosis (multiple); renal cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human JUP (junction plakoglobin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Jup |
| Official Name | junction plakoglobin [Source:MGI Symbol;Acc:MGI:96650] |
| Ensembl ID | ENSMUSG00000001552 |
| Bio databases IDs | |
| Aliases | junction plakoglobin |
| Synonyms | CTNNG, CTNN γ, D930025P04Rik, DP3, DPIII, gamma-CATENIN, junction plakoglobin, PDGB, PG, PKGB, Plakoglobin, γ-CATENIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Jup often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Armadillo/beta-catenin-like repeat
- alpha-catenin binding
- protein kinase binding
- cell adhesion molecule binding
- protein phosphatase binding
- protein binding activity, bridging
- protein binding
- head domain
- cytoskeletal adaptor
- N-cadherin binding domain
- binding protein
- alpha catenin-binding domain
- Armadillo/beta-catenin-like repeats
- protein homodimerization
- cadherin binding
- tail domain
- CTNNAbd_CTNNB1-like
Pathways
Biological processes and signaling networks where the Jup gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- epithelial cancer
- Naxos disease
- melanoma
- melanoma cancer
- arrhythmogenic right ventricular dysplasia familial 12
- atrial thrombosis
- colorectal cancer
- arrhythmogenic right ventricular cardiomyopathy
- palmoplantar keratoderma
phenotypes
- abnormal craniofacial morphology
- abnormal embryo size
- abnormal facial morphology
- abnormal placenta size
- abnormal tail morphology
- decreased coping response
- decreased fasting circulating glucose level
- increased hemoglobin content
- preweaning lethality complete penetrance
- abnormal atrial thrombosis
- abnormal atrioventricular cushion morphology
- abnormal blood circulation
- abnormal cardiac muscle contractility
- abnormal epidermal layer morphology
- abnormal epidermis stratum granulosum morphology
- abnormal epidermis stratum spinosum morphology
- abnormal fasting circulating glucose level
- abnormal fat cell differentiation
- abnormal heart atrium morphology
- abnormal heart development
- abnormal heart echocardiography feature
- abnormal heart morphology
- abnormal intercalated disk morphology
- abnormal liver morphology
- abnormal skin physiology
- abnormal spongiotrophoblast layer morphology
- abnormal thrombosis
- absent cardiac desmosomes
- absent epidermis stratum corneum
- acantholysis
- blistering
- decreased skin tensile strength
- decreased spongiotrophoblast size
- embryonic growth retardation
- embryonic lethality
- embryonic lethality during organogenesis incomplete penetrance
- enlarged heart
- hemopericardium
- impaired skin barrier function
- increased heart rate
- lethality throughout fetal growth and development complete penetrance
- loose skin
- neonatal lethality complete penetrance
- no abnormal phenotype detected
- pallor
- small liver
- small placenta
- thin epidermis
- thin interventricular septum
- thin myocardium
- trabecula carnea hypoplasia
- wrinkled skin
role in cell
- expression in
- apoptosis
- proliferation
- survival
- clustering
- migration
- growth
- transformation
- differentiation
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- nuclear fraction
- detergent-insoluble fractions
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- apicolateral membrane
- cornified envelope
- cell junction
- secretory granule lumen
- ficolin-1-rich granule lumen
- cytoskeleton
- Cytoplasm
- cell surface
- cell borders
- Extracellular Space
- perinuclear region
- intracellular membranes
- cellular membrane
- actin cytoskeleton
- Nucleus
- intermediate filaments
- myofilaments
- intercellular junctions
- desmosomes
- cell-cell contacts
- cytosol
- cytoplasmic face of plasma membrane
- endoplasmic reticulum buds
- caveolar membranes
- apical membrane
- basolateral membrane
- lateral plasma membrane
- intercalated disks
- Z line
- anchoring junction
- junctional complexes
- zonula adherens
- lateral cell-cell contacts
- microsomal membrane
- cell-cell adherens junctions
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Jup gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of blood vessel endothelial cell migration
- positive regulation of protein import into nucleus
- positive regulation of canonical Wnt receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of sequence-specific DNA binding transcription factor activity
- skin development
- regulation of cell proliferation
- positive regulation of angiogenesis
- detection of mechanical stimulus
- desmosome assembly
- cellular response to indole-3-methanol
- positive regulation of cell-matrix adhesion
- canonical Wnt receptor signaling pathway
- regulation of heart rate by cardiac conduction
- cell migration
- bundle of His cell-Purkinje myocyte adhesion involved in cell communication
- protein localization in plasma membrane
- endothelial cell-cell adhesion
Cellular Component
Where in the cell the gene product is active
- specific granule lumen
- intermediate filament
- extracellular region
- plasma membrane
- internal side of plasma membrane
- Z disc
- nucleus
- adherens junction
- cornified envelope
- extracellular vesicular exosome
- cytoskeleton
- cell-cell junction
- focal adhesion
- cytoplasm
- zonula adherens
- protein-DNA complex
- cytosol
- intercalated disc
- catenin complex
- desmosome
- hemidesmosome
- gamma-catenin-TCF7L2 complex
Molecular Function
What the gene product does at the molecular level
- alpha-catenin binding
- ligand-dependent nuclear receptor binding
- protein binding
- protein phosphatase binding
- protein homodimerization activity
- transcription coactivator activity
- cadherin binding
- cell adhesion molecule binding
- structural molecule activity
- cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication