Axin2 Gene Summary [Mouse]
Enables I-SMAD binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including heart valve morphogenesis; negative regulation of canonical Wnt signaling pathway; and regulation of centromeric sister chromatid cohesion. Acts upstream of or within several processes, including negative regulation of osteoblast differentiation; negative regulation of osteoblast proliferation; and regionalization. Located in centrosome and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study craniosynostosis. Human ortholog(s) of this gene implicated in endometrial adenocarcinoma; gastrointestinal system cancer (multiple); lung cancer (multiple); and orofacial cleft. Orthologous to human AXIN2 (axin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Axin2 |
| Official Name | axin 2 [Source:MGI Symbol;Acc:MGI:1270862] |
| Ensembl ID | ENSMUSG00000000142 |
| Bio databases IDs | |
| Aliases | axin 2 |
| Synonyms | Axi1, AXIL, Conductin, LOC102724272, ODCRCS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Axin2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of G protein signaling domain
- SMAD binding
- ubiquitin protein ligase binding
- DIX domain
- protein kinase binding
- beta-catenin binding
- Axin beta-catenin binding motif
- enzyme binding
- Regulator of G protein signaling (RGS) domain superfamily
- Tankyrase binding N-terminal segment of axin
- protein binding
Pathways
Biological processes and signaling networks where the Axin2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- gastrointestinal tract cancer
- chronic obstructive pulmonary disease
- hereditary cancer-predisposing syndrome
- preeclampsia
role in cell
- phosphorylation in
- expression in
- growth
- apoptosis
- migration
- activation in
- proliferation
- signaling in
- differentiation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Axin2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization
- positive regulation of fat cell differentiation
- dorsal/ventral axis specification
- odontogenesis
- negative regulation of osteoblast differentiation
- positive regulation of epithelial to mesenchymal transition
- maintenance of DNA repeat elements
- stem cell proliferation
- osteoblast differentiation
- canonical Wnt receptor signaling pathway
- regulation of chondrocyte development
- regulation of mismatch repair
- regulation of centromeric sister chromatid cohesion
- bone mineralization
- aortic valve morphogenesis
- mitral valve morphogenesis
- cell development
- negative regulation of canonical Wnt receptor signaling pathway
- chondrocyte differentiation involved in endochondral bone morphogenesis
- proteasomal ubiquitin-dependent protein catabolic process
- secondary heart field specification
- positive regulation of protein kinase activity
- somitogenesis
- positive regulation of protein phosphorylation
- mRNA stabilization
- intramembranous ossification
- osteoblast proliferation
- cellular response to dexamethasone stimulus
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of osteoblast proliferation
Cellular Component
Where in the cell the gene product is active
- beta-catenin destruction complex
- nucleus
- centrosome
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ubiquitin protein ligase binding
- protein binding
- beta-catenin binding
- I-SMAD binding
- binding, bridging
- enzyme binding