Arid5b Gene Summary [Mouse]
Predicted to enable transcription cis-regulatory region binding activity and transcription coactivator activity. Involved in adipose tissue development. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; face morphogenesis; and gonad development. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human ARID5B (AT-rich interaction domain 5B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arid5b |
| Official Name | AT rich interactive domain 5B (MRF1-like) [Source:MGI Symbol;Acc:MGI:2175912] |
| Ensembl ID | ENSMUSG00000019947 |
| Bio databases IDs | |
| Aliases | AT rich interactive domain 5B (MRF1-like) |
| Synonyms | 4930580B11, 5430435G07Rik, AT-rich interaction domain 5B, DESRT, DKFZP586N012, Mrf1-like, MRF-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arid5b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- double-stranded DNA binding
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- ARID/BRIGHT DNA binding domain
- DNA binding
- ARID/BRIGHT DNA binding domain family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- non-insulin-dependent diabetes mellitus
- lung adenocarcinoma
- lung adenocarcinoma formation
- acute lymphoblastic leukemia
- hypothyroidism
- glioblastoma
- glioblastoma cancer
- childhood acute lymphoblastic leukemia
- systemic lupus erythematosus
phenotypes
- abnormal adipose tissue morphology
- abnormal adrenal gland zona reticularis morphology
- abnormal cell migration
- abnormal endochondral bone ossification
- abnormal fat cell morphology
- abnormal female reproductive system morphology
- abnormal fertility/fecundity
- abnormal frontal bone morphology
- abnormal immune system organ morphology
- abnormal kidney morphology
- abnormal kidney physiology
- abnormal long bone epiphyseal plate morphology
- abnormal long bone hypertrophic chondrocyte zone
- abnormal lymphopoiesis
- abnormal male reproductive system morphology
- abnormal mating frequency
- abnormal mating receptivity
- abnormal neurocranium morphology
- abnormal ovary morphology
- abnormal palate morphology
- abnormal renal glomerulus morphology
- abnormal skeleton morphology
- abnormal smooth muscle morphology
- abnormal sternum morphology
- abnormal vertebrae morphology
- abnormal vertebral arch morphology
- absent corpus luteum
- absent mature ovarian follicles
- arrest of spermatogenesis
- asymmetric sternocostal joints
- broad snout
- cryptorchism
- decreased body length
- decreased body size
- decreased body weight
- decreased bone marrow cell number
- decreased brown adipose tissue amount
- decreased brown fat lipid droplet number
- decreased double-positive T cell number
- decreased fibroblast cell migration
- decreased food intake
- decreased palatine bone horizontal plate size
- decreased percent body fat/body weight
- decreased pro-B cell number
- decreased susceptibility to diet-induced obesity
- decreased white adipose tissue amount
- female infertility
- increased blood urea nitrogen level
- increased food intake
- increased single-positive T cell number
- kidney inflammation
- neonatal lethality incomplete penetrance
- pale kidney
- perinatal lethality incomplete penetrance
- poor grooming
- postnatal growth retardation
- postnatal lethality
- reduced male fertility
- seminiferous tubule degeneration
- short maxilla
- short nasal bone
- short premaxilla
- short snout
- short tibia
- slow postnatal weight gain
- small endometrial glands
- small kidney
- small presphenoid bone
- small testis
- small uterus
- spleen hypoplasia
- thymus cortex hypoplasia
- thymus hypoplasia
role in cell
- apoptosis
- number
- differentiation
- expression in
- binding in
- proliferation
- development
- production in
- quantity
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arid5b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- male gonad development
- post-embryonic development
- palate development
- fat pad development
- platelet-derived growth factor receptor signaling pathway
- cell development
- fat cell differentiation
- muscle organ morphogenesis
- female gonad development
- positive regulation of sequence-specific DNA binding transcription factor activity
- skeletal system morphogenesis
- face morphogenesis
- regulation of transcription from RNA polymerase II promoter
- adipose tissue development
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- kidney development
- positive regulation of transcription, DNA-dependent
- liver development
- fibroblast migration
- adrenal gland development
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- transcription coactivator activity
- transcription regulatory region sequence-specific DNA binding