Tagln Gene Summary [Mouse]
This gene encodes a smooth muscle cell-specific cytoskeletal protein. The encoded protein is structurally similar to calponin, an actin-binding protein. In mouse models of atherosclerosis the gene product may be involved in plaque cell and atherosclerotic lesion formation during atherogenesis. [provided by RefSeq, Mar 2010]
Details
| Type | Protein Coding |
| Official Symbol | Tagln |
| Official Name | transgelin [Source:MGI Symbol;Acc:MGI:106012] |
| Ensembl ID | ENSMUSG00000032085 |
| Bio databases IDs | |
| Aliases | transgelin |
| Synonyms | SM22, Sm22a, SM22 alpha, SM22 α, SMCC, TAGL, TAGLN1, TGLN, Transgelin, WS3-10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tagln often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- actin-binding domain
- PKC phosphorylation site
- Calponin homology domain
- protein binding activity, bridging
- Calponin family repeat
- calponin homology (CH) domain superfamily
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- psoriasis
- prostate cancer
- osteosarcoma
- osteosarcomagenesis
- hypertension
- chronic sinusitis
- breast carcinoma
- autosomal dominant polycystic kidney disease
- keratocystic odontogenic tumor
role in cell
- degradation in
- cell viability
- apoptosis
- differentiation
- proliferation
- invasiveness
- contraction
- quantity
- function
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- actin filaments
- actin bundles
- myosin filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tagln gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- muscle organ development
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding