Hdac2 Gene Summary [Mouse]
Enables several functions, including DNA binding activity; Krueppel-associated box domain binding activity; and hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Involved in several processes, including circadian regulation of gene expression; eyelid development in camera-type eye; and negative regulation of DNA-templated transcription. Acts upstream of or within several processes, including cellular response to trichostatin A; nervous system development; and regulation of signal transduction. Located in heterochromatin; nucleus; and replication fork. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human HDAC2 (histone deacetylase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hdac2 |
| Official Name | histone deacetylase 2 [Source:MGI Symbol;Acc:MGI:1097691] |
| Ensembl ID | ENSMUSG00000019777 |
| Bio databases IDs | |
| Aliases | histone deacetylase 2 |
| Synonyms | D10Wsu179e, HD2, histone deacetylase 2, KDAC2, mRPD3, RGD: 619976, RPD3, YAF1, Yy1bp |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hdac2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- transcription regulator
- nucleic acid binding
- NF-kappaB binding
- heat shock protein binding
- deacetylase motif
- nuclear localization sequence
- enzyme binding
- transcription factor binding
- histone deacetylase binding
- chromatin binding
- protein domain specific binding
- enzyme
- deacetylase
- protein binding
- sequence-specific DNA binding
- DNA binding
- Arginase-like and histone-like hydrolases
- phosphorylation site
- protein deacetylase activity
- double-stranded DNA binding
- linear amide carbon-nitrogen bond hydrolase
- histone deacetylase
Pathways
Biological processes and signaling networks where the Hdac2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Bladder Cancer Signaling
- Calcium Signaling
- Calcium-induced T Lymphocyte Apoptosis
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- DNA Methylation and Transcriptional Repression Signaling
- Glioma Signaling
- Hereditary Breast Cancer Signaling
- Huntington's Disease Signaling
- Molecular Mechanisms of Cancer
- NF-κB Signaling
- Non-Small Cell Lung Cancer Signaling
- Nur77 Signaling in T Lymphocytes
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Role of NFAT in Cardiac Hypertrophy
- Small Cell Lung Cancer Signaling
- Telomerase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- human immunodeficiency virus I infection
- non-insulin-dependent diabetes mellitus
- rheumatoid arthritis
- breast cancer
- neoplasia
- non-uveal melanoma
- organismal death
- asthma
- metastatic colorectal adenocarcinoma
- postmenopausal breast cancer
role in cell
- growth
- phosphorylation in
- expression in
- apoptosis
- quantity
- cell death
- migration
- formation
- binding in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- Cytoplasm
- nucleoplasm
- nuclear speckles
- DNA replication foci
- telomeres
- chromatin
- replication fork
- perikaryon
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hdac2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to hyperoxia
- protein modification process
- regulation of cell fate specification
- positive regulation of tyrosine phosphorylation of STAT protein
- embryonic digit morphogenesis
- positive regulation of oligodendrocyte differentiation
- circadian regulation of gene expression
- positive regulation of collagen biosynthetic process
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- negative regulation of peptidyl-lysine acetylation
- negative regulation of neuron projection development
- positive regulation of tumor necrosis factor production
- negative regulation of dendritic spine development
- response to cocaine
- negative regulation of sequence-specific DNA binding transcription factor activity
- cardiac muscle hypertrophy
- cellular response to transforming growth factor beta stimulus
- epidermal cell differentiation
- negative regulation of transcription by competitive promoter binding
- heterochromatin assembly
- negative regulation of cell migration
- positive regulation of cell proliferation
- fungiform papilla formation
- hair follicle placode formation
- negative regulation of MHC class II biosynthetic process
- odontogenesis of dentin-containing tooth
- positive regulation of proteolysis
- response to xenobiotic stimulus
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of epithelial to mesenchymal transition
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- cellular response to heat
- regulation of stem cell differentiation
- cellular response to hydrogen peroxide
- dendrite development
- positive regulation of receptor activity
- response to nicotine
- behavioral response to ethanol
- eyelid development in camera-type eye
- response to amphetamine
- cellular response to retinoic acid
- negative regulation of apoptotic process
- response to caffeine
- response to lipopolysaccharide
- negative regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of interleukin-1 production
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- cytoplasm
- ESC/E(Z) complex
- NuRD complex
- histone deacetylase complex
- macromolecular complex
- chromatin
- nucleoplasm
- Sin3-type complex
Molecular Function
What the gene product does at the molecular level
- NF-kappaB binding
- heat shock protein binding
- protein binding
- RNA binding
- histone deacetylase binding
- histone deacetylase activity
- histone binding
- nucleosomal DNA binding
- chromatin binding
- protein deacetylase activity
- enzyme binding