H2az1 Gene Summary [Mouse]
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | H2az1 |
| Official Name | H2A.Z variant histone 1 [Source:MGI Symbol;Acc:MGI:1888388] |
| Ensembl ID | ENSMUSG00000037894 |
| Bio databases IDs | |
| Aliases | H2A.Z variant histone 1 |
| Synonyms | H2AFZ, H2AZ, H2A/z, H2A.Z, H2A.Z-1, H2A.Z variant histone 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse H2az1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- binding protein
- double-stranded DNA binding
- C-terminus of histone H2A
- nucleic acid binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- Histone 2A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- metastasis
- psoriasis
- delayed hypersensitive reaction
- hepatocellular carcinoma
- glioma formation
- glioma
role in cell
- expression in
- accumulation in
- activation in
- proliferation
- morphology
- apoptosis
- G1 phase
- binding in
- differentiation
- senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- autosome
- heterochromatin
- nucleosomes
- chromosomal arms
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse H2az1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to estradiol stimulus
- heterochromatin assembly
- positive regulation of transcription from RNA polymerase II promoter
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- Barr body
- nucleus
- heterochromatin
- euchromatin
- extracellular vesicular exosome
- nucleosome
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- structural constituent of chromatin
- protein binding
- protein heterodimerization activity
- RNA polymerase II core promoter sequence-specific DNA binding
- nucleosomal DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding