PRCC Gene Summary [Human]
This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010]
Details
| Type | Processed Transcript |
| Official Symbol | PRCC |
| Official Name | proline rich mitotic checkpoint control factor [Source:HGNC Symbol;Acc:HGNC:9343] |
| Ensembl ID | ENSG00000143294 |
| Bio databases IDs | |
| Aliases | proline rich mitotic checkpoint control factor |
| Synonyms | papillary renal cell carcinoma (translocation-associated), proline rich mitotic checkpoint control factor, RCCP1, TPRC |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRCC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Mitotic checkpoint regulator, MAD2B-interacting
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- papillary renal cell carcinoma
- papillary renal cell neoplasia
- renal cell cancer
- gastric epithelial cancer
- yolk sac tumor and high-grade immature teratoma
- germ cell cancer
- gastric carcinoma
- diffuse systemic sclerosis
regulates
role in cell
- cell cycle progression
- cell death
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear speckles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRCC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding