Prcc Gene Summary [Mouse]
Predicted to be involved in regulation of cell cycle. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Human ortholog(s) of this gene implicated in papillary renal cell carcinoma. Orthologous to human PRCC (proline rich mitotic checkpoint control factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prcc |
| Official Name | papillary renal cell carcinoma (translocation-associated) [Source:MGI Symbol;Acc:MGI:2137738] |
| Ensembl ID | ENSMUSG00000004895 |
| Bio databases IDs | |
| Aliases | papillary renal cell carcinoma (translocation-associated) |
| Synonyms | papillary renal cell carcinoma (translocation-associated), proline rich mitotic checkpoint control factor, RCCP1, TPRC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prcc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Mitotic checkpoint regulator, MAD2B-interacting
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- papillary renal cell carcinoma
- papillary renal cell neoplasia
- renal cell cancer
- gastric epithelial cancer
- yolk sac tumor and high-grade immature teratoma
- germ cell cancer
- gastric carcinoma
- diffuse systemic sclerosis
regulates
role in cell
- cell cycle progression
- cell death
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear speckles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prcc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding